Biodegradable triblock copolymers, synthesis methods...

Details Biodegradable triblock copolymers, synthesis methods... Biodegradable triblock copolymers, synthesis methods...

2007-11-20

2007-11-20

Hartley, Michael G. (Department: 1618)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

C424S486000

Reexamination Certificate

active

10624136

ABSTRACT:
A drug delivery system that includes a hydrogel formed from cyclodextrin and an amphiphilic copolymer that includes an A polymer block comprising a poly(alkylene oxide) and a B polymer block comprising a poly(hydroxyalkanoate), and a therapeutically effective amount of at least one therapeutic agent intimately contained within the hydrogel. In one preferred embodiment of the invention, the A polymer block is poly(ethylene oxide) (PEO) and the B polymer block is poly[(R)-3-hydroxybutyrate] (PHB), and the copolymer is the triblock ABA copolymer PEO-PHB-PEO. A method of synthesizing the amphiphilic triblock copolymer is also provided.

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