Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1998-10-02
2000-11-28
Azpuru, Carlos A.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
5147723, A61F 202, A61K 4730
Patent
active
061532126
ABSTRACT:
A medical device is described comprising a biodegradable terephthalate copolymer comprising the recurring monomeric units shown in formula I below: ##STR1## wherein R is a divalent organic moiety; R' is an aliphatic, aromatic, or heterocyclic residue; x is .gtoreq.1; and n is 3-7,500, and where the biodegradable terephthalate copolymer is sufficiently pure to be biocompatible and is capable of forming biocompatible residues upon biodegradation. In addition, compositions containing the copolymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the copolymers, are also described.
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Dang Wenbin
English James P.
Leong Kam W.
Mao Hai-quan
Nowotnik David P.
Azpuru Carlos A.
Guilford Pharmaceuticals Inc.
Johns Hopkins University School of Medicine
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