Biodegradable scaffold with ECM material

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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Reexamination Certificate

active

08053559

ABSTRACT:
We add discontinuous regions of Extra Cellular Matrix (ECM) to a biodegradable scaffold. Hereby it is possible to combine the range of physical properties the scaffold can offer with the reconstructive properties of the ECM. The optimal amount of discrete ECM material for each application is disclosed and this concentration is equally distributed in the dressing hence avoiding unnecessary high concentrations of ECM. In addition to the effect of the ECM, the porous structure of the base material provides the cells with a structure for in-growth.

REFERENCES:
patent: 5709934 (1998-01-01), Bell et al.
patent: 5749895 (1998-05-01), Sawyer et al.
patent: 5800537 (1998-09-01), Bell
patent: 5866165 (1999-02-01), Liu et al.
patent: 5891558 (1999-04-01), Bell et al.
patent: 5948429 (1999-09-01), Bell et al.
patent: 7569233 (2009-08-01), Malaviya et al.
patent: 2004/0110439 (2004-06-01), Chaikof et al.
patent: 1 481 694 (2004-12-01), None
patent: 1 498 128 (2005-01-01), None
patent: WO 97/18842 (1997-05-01), None
patent: WO 00/16818 (2000-03-01), None
Badylak, S.F., et al., “The Extracellular Matrix as a Scaffold for Tissue Reconstruction,” Semin. Cell Dev. Biol. Oct. 2002, vol. 13, No. 5, pp. 377-383.
Badylak, S.F., et al., “Small Intestinal Submucosa: a substrate for in vitro cell growth,” J. Biomater. Sci. Polym. Ed., vol. 9, pp. 863-878, Feb. 1998.
Lindberg, K., et al., “Porcine Small Intestine Submucosa (SIS): a bioscaffold supporting in vitro primary human epidermal cell differentiation and synthesis of basement membrane proteins,” Burns, May 2001, vol. 27, No. 3, pp. 254-266.
Hodde, J.P., et al., “Vascular Endothelial Growth Factor in Porcine-Derived Extracellular Matrix,” Endothelium, 2001, vol. 8, No. 1, pp. 11-24.
Voytik-Harbin, S.L., et al., “Identification of Extractable Growth Factors from Small Intestinal Submucosa,” J. Cell Biochem, 1997, vol. 67, pp. 478-491.
McDevitt, C.A., et al., “Transforming Growth Factor-beta1 in a Sterilized Tissue Derived from the Pig Small Intestine Submucosa,” J. Biomed. Mater. Res. Nov. 2003, 1;67A (2): vol. 67A, pp. 637-640.
Gilbert, T.W., “Production and Characterization of ECM Powder: Implications for Tissue Engineering Applications,” Biomaterials, vol. 26, No. 12, 2005, pp. 1431-1435.
Pandit, A., et al., “The Effect of TGF-beta Delivered Through a Collagen Scaffold on Wound Healing,” J. Invest. Surg., vol. 12, No. 2, 1999, pp. 89-100.
Pandit, A. et al., “Investigation of Cidic Fibroblast Growth Factor Delivered Through a Collagen Scaffold for the Treatment of Full-Thickness Skin Defects in a Rabbit Model,” Plast. Reconstr. Surg., vol. 101, No. 3, 1998, pp. 766-775.
Pandit, A., et al., “Fibrin Scaffold as an Effective Vehicle for the Delivery of Acidic Fibroblast Growth Factor (FGF-1),” J. • Biomater. Appl., vol. 14, No. 3, 2000, pp. 229-242.
Obara, K., et al., “Acceleration of Wound Healing in Healing-Impaired db/db mice with a Photocrosslinkable Chitosan Hydrogel Containing Fibroblast Growth Factor-2,” Wound. Repair Regen., vol. 13, No. 4, 2005, pp. 390-397.
Yamamoto, M., et al., “Bone Regeneration by Transforming Growth Factor Beta1 Released from a Biodegradable Hydrogel,” J. Control Release, vol. 64, No. 1-3, 2000, pp. 133-142.
Miyoshi, M., et al., “Effects of bFGF Incorporated into a Gelatin Sheet on Wound Healing,” J. Biomater. Sci. Polym. Ed. vol. 16, No. 7, 2005, pp. 893-907.
Ulubayram, K., et al., “EGF Containing Gelatin-Based Wound Dressings,” Biomaterials, vol. 22, No. 11, 2001, pp. 1345-1356.

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