Biodegradable polyphosphoramidates for controlled release of...

Details Biodegradable polyphosphoramidates for controlled release of... Biodegradable polyphosphoramidates for controlled release of...

2002-05-14

2008-08-26

Truong, Duc (Department: 1796)

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

From phosphorus-containing reactant

C528S399000, C528S422000, C528S425000, C524S501000, C524S708000, C524S710000, C424S001770, C424S457000

Reexamination Certificate

active

07417110

ABSTRACT:
The present invention is directed to a series of new polycationic biodegradable polyphosphoramidates. Process for making the polymers, compositions containing these polymers and bioactive ligands to enhance the cellular uptake ad intracellular trafficking, articles and methods for delivery of drugs and genes using these polymers are described. A gene delivery system based on these polymers is prepared by complex coacervation of nucleic acid (DNA or RNA) with polymers. Targeting ligands and molecules that could facilitate gene transfer can be conjugated to polymers to achieve selective and enhanced gene delivery. The current invention also provides a complex composition with buffering capacity.

REFERENCES:
patent: 5194581 (1993-03-01), Leong
HCA 78:30806.
HCA 107:116051.

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