Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – From carboxylic acid or derivative thereof
Reexamination Certificate
2008-03-18
2008-03-18
Nutter, Nathan M. (Department: 1796)
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
From carboxylic acid or derivative thereof
C528S398000
Reexamination Certificate
active
10499898
ABSTRACT:
The present invention is directed to a biodegradable system for the controlled release of bioactive substances. This system comprises novel biodegradable and biocompatible polyphosphoesters that carry positive charges. Process for making these polyphosphoesters, compositions containing these polyphosphoesters and biologically active substances, articles and methods for delivery of drugs and genes using this system are described. A controlled gene delivery system based on these polyphosphoesters is prepared by complex coacervation of nucleic acid (DNA or RNA) with polymers. The release rates can be manipulated by adjusting the charge ratios of polyphosphoesters to nucleic acids. This gene delivery system yields a higher gene expression in muscle when injected intramuscularly.
REFERENCES:
patent: 6852709 (2005-02-01), Leong et al.
patent: WO 8301778 (1983-05-01), None
CA 123:144517 “Amino acids coupled to poly(alkylene phosphates”, Penczek et al.
Leong Kam Weng
Mao Hai-Quan
Wang Jun
Gluck Peter J.
Greenberg & Traurig
Johns Hopkins Singapore PTE Ltd.
Nutter Nathan M.
Walker Marlan D.
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