Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ortho-hydroxybenzoic acid or derivative doai
Reexamination Certificate
2006-06-04
2011-11-29
Seidleck, James J (Department: 1765)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ortho-hydroxybenzoic acid or derivative doai
C528S271000, C528S272000, C528S288000, C528S291000, C528S363000, C524S017000, C524S599000, C530S300000, C424S078080, C424S094100, C424S408000, C424S409000, C424S426000, C349S133000
Reexamination Certificate
active
08067398
ABSTRACT:
Optically active polymers that are composed of monomer residues derived from chiral pre-polymerized monomers, which maintain the chirality of the pre-polymerized monomers upon polymerization are disclosed. These polymers can be composed of monomer residues that are derived from readily available chiral monomers and can be designed to have pre-determined characteristics such as chirality, biodegradability and functionality. Uses of these polymers as therapeutically active agents, and/or as carriers of therapeutically active agents, for delivering the active agents to a targeted bodily site and/or for a sustained release of the active agent, are further disclosed. Also disclosed are processed of preparing the polymers, compositions and medical devices containing the polymers, and conjugates of these polymers and various agents.
REFERENCES:
patent: 4326031 (1982-04-01), Wandrey et al.
patent: 4999417 (1991-03-01), Domb
patent: 5098841 (1992-03-01), Ghisalba et al.
patent: 5686275 (1997-11-01), Casey et al.
patent: 5844068 (1998-12-01), Otera et al.
patent: 7622544 (2009-11-01), Braun
patent: WO 99/36100 (1999-07-01), None
patent: WO 02/16552 (2002-02-01), None
patent: WO 02/33110 (2002-04-01), None
patent: WO 2007/050732 (2004-06-01), None
patent: WO 2006/129320 (2006-12-01), None
Bou et al. “Optically Active Polyamides Derived From L-Tartaric Acid”, Macromolecules, 26(21): 5664-5670, 1993. Scheme 1, Experimental Part.
Hrkach et al. “Synthesis of Poly(L-Lactic Acid-Co-L-Lysine) Graft Copolymers”, Macromolecules, 28(13): 4736-4739, 1995. Experimental Partfig.1 .
Kuisle et al. “Solid Phase Synthesis of Depsides and Depsipeptides”, Tetrahedron Letters, 40(6): 1203-1206, 1999. Scheme 1, 2.
Communication Relating to the Results of the Partial International Search Dated Oct. 10, 2006 From the International Searching Authority Re.: Application No. PCT/IL2006/000643.
International Preliminary Report on Patentability Dated Dec. 21, 2007 From the International Bureau of WIPO Re.: Application No. PCT/IL2006/000643.
Communication Pursuant to Article 94(3) EPC Dated Jul. 29, 2009 From the European Patent Office Re.: Application No. 06756190.2.
Communication Pursuant to Article 94(3) EPC Dated Apr. 16, 2008 From the European Patent Office Re.: Application No. 06756190.2.
International Search Report Dated Dec. 4, 2006 From the International Searching Authority Re.: Application No. PCT/1L2006/000643.
Partial International Search Report Dated Oct. 10, 2006 From the International Searching Authority Re.: Application No. PCT/IL2006/000643.
Written Opinion Dated Dec. 4, 2006 From the International Searching Authority Re.: Application No. PCT/1L2006/000643.
Bishara et al. “PLA Stereocomplexes for Controlled Release of Somatostatin Analogue”, Journal of Controlled Release, 107: 474-483, 2005.
Bonthrone et al. “The Biological and Physical Chemistry of Polyhydroxyalkanoates as Seen by NMR Spectroscopy”, FEMS Microbiology Reviews, 103: 269-278, 1992.
Brandl et al. “Plastics From Bacteria and for Bacteria: Poly(?-Hydroxy-Alkanoates) as Natural, Biocompatible, and Biodegradable Polyesters”, Advances in Biochemical Engineering/Biotechnology, 41: 787-793, 1990.
Corey et al. “A New System for Catalytic Enantioselective Reduction of Achiral Ketones to Chiral Alcohols. Synthesis of Chiral ?-Hydroxy Acids”, Tetrahedron Letters, 31(5): 611-614, 1990. Mergaert et al. “Biodegradation of Polyhydroxyalkanoates”, FEMS Microbiology Reviews, 103: 317-322, 1992.
Reddy et al. “Chirality and Its Implications in Transdermal Drug Development”, Critical Reviews in Therapeutic Drug Carrier Systems, 17(4): 285-325, 2000.
Seebach et al. “Detection, Synthesis, Structure, and Function of Oligo(3- Hydroxyalkanoates): Contributions by Synthetic Organic Chemists”, International Journal of Biological Macromolecules, 25: 217-236, 1999.
Stager et al. “Biopolymer Stereocomplexes”, Advanced Drug Delivery Reviews, 55: 549-583, 2003.
Stager et al. “Hetero-Stereocomplexes of D-Poly(Lactic Acid) and the LHRH Analogue Leuprolide. Application in Controlled Release”, European Journal of Pharmaceutics and Biopharmaceutics, 58: 461-469, 2004.
Slager et al. “Heterostereocomplexes Prepared From D-PLA and L-PLA and Leuprolide. II Release of Leuprolide”, Biomacromolecules, 4: 1316-1320, 2003.
Slager et al. “Heterostereocomplexes Prepared From D-Poly(Lactide) and Leuprolide. I. Characterization”, Biomacromolecules, 4: 1308-1315, 2003.
Slager et al. “Peptides Form Stereoselective Complexes With Chiral Polymers”, Macromolecules, 36: 2999-3000, 2003.
Slager et al. “Stereocomplexes Based on Poly(Lactic acid) and Insulin: Formulation and Release Studies”, Biomaterials, 23: 4389-4396, 2002.
Vert et al. “New Insights on the Degradation of Bioresorbable Polymeric Devices Based on Lactic and Glycolic Acids”, Clinical Materials, 10: 3-8, 1992.
References Considered Except W I-Ere Lined Ti Irougi I.
Domb Abraham Jackob
Katzhendler Yehoshua
Seidleck James J
Tischler Frances
Yissum Research Development Company of the Hebrew University of
LandOfFree
Biodegradable polymers having a pre-determined chirality does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Biodegradable polymers having a pre-determined chirality, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biodegradable polymers having a pre-determined chirality will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4256244