Biodegradable polymers for cell transplantation

Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – From carboxylic acid or derivative thereof

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424 7819, 424426, 424484, 424486, 435180, 435181, 435182, 514 1, 514 2, 528357, 528361, 530815, C08G 6308, C08G 6900, C08G 6912

Patent

active

053996658

ABSTRACT:
Polymers more suitable for use in organ transplantation are formed by coupling biologically active moieties to the free amino groups of polymers formed by incorporation of .alpha. amino acids into polymers formed of alpha hydroxy acids such as lactic acids. In the preferred embodiment, the peptides are coupled to the free amino groups.

REFERENCES:
patent: 2668162 (1954-02-01), Lowe
patent: 2676945 (1954-04-01), Higgins
patent: 3839297 (1974-10-01), Wasserman et al.
patent: 4048256 (1977-09-01), Casey et al.
patent: 4673566 (1987-06-01), Goosen et al.
patent: 4689293 (1987-08-01), Goosen et al.
patent: 4696286 (1987-09-01), Cochrum
patent: 4806355 (1989-02-01), Goosen et al.
patent: 5010167 (1991-04-01), Ron et al.
patent: 5248761 (1993-09-01), Hermes
Bumgardner, G. I., Fasola, C. and Sutherland D. F. R., "Prospects for Hepatocyte Transplantation," Hepatology, vol. 8, pp. 1158-1161 (1988).
Cima, L., Ingber, D., Vacanti, J., and Langer, R. "Hepatocyte Culture on Biodegradable Polymeric Substrates," Biotech. Bioeng., vol. 38, pp. 145-158 (1991).
Cima, L., et al., "Tissue Engineering by Cell Transplantation Using Degradable Polymer Substrates," J. Biomech. Eng., vol. 113, pp. 143-151 (1991).
Craig, P. H., et al., "A Biologic Comparison of Polyglactin 910 and Polyglycolic Acid Synthetic Absorbable Sutures," Surgery, vol. 141, pp. 1-10 (1975).
Dawson, R. M., Broughton, R. L., Stevenson, W. T. K. and Sefton, M. V., "Microencapsulation of CHO Cells in a Hydroxyethyl Methacrylate-Methyl Methacrylate Copolymer," Biomaterials, vol. 8, pp. 360-366 (1987).
Frazza, E. J. and Schmitt, E. E., "A New Absorbable Suture," J. Biomed. Mater. Res. Symposium, vol. 1, pp. 43-58 (1971).
Gilding, D. K. and Reed, A. M., "Biodegradable Polymers for Use in Surgery-Polyglycolic/Poly(lactic acid) Homo-and Co-polymers": 1, Polymer, vol. 20, pp. 1459-1464 (1979).
Jaffe, V., Darby, H. and Selden, C., "The Growth of Transplanted Liver Cells within the Pancreas," Transplantation, vol. 45, pp. 497-498 (1987).
Lim, F., "Microencapsulation of Living Cells and Tissues," Applied Biochemistry and Biotechnology, vol. 10, pp. 81.85 (1984).
Ricordi, C., Flye, M. W. and Lacy, P. E., "Renal Subcapsular Transplantation of Clusters of Hepatocytes in Conjunction with Pancreatic Islets," Transplantation, vol. 45, pp. 1148-1151 (1987).
Sun, A. M., O'Shea, G. M. and Goosen, M. F. A., "Injectable Microencapsulated Islet Cells as a Bioartificial Pancreas," Applied Biochemistry and Biotechnology, vol. 10, pp. 87-89 (1984).
Sun, A. M., et al., "Microencapsulated Hepatocytes: An in Vitro and in Vivo Study," Biomat. Art. Cells. Art. Org., vol. 15, pp. 483-496 (1987).
Vacanti, J. P., "Beyond Transplantation, Third Annual Samuel Jason Mixter Lecture," Archives of Surgery, vol. 123, pp. 545-549 (1988).
Wong, H. and Chang, T. M. S., "The Viability and Regeneration of Artificial Cell Microencapsulated Rat Hepatocyte Xenograft Transplants in Mice," Biomat., Art. Cells, Art. Org., vol. 16, pp. 731-739 (1988).
Brode, G. L. and Koleske, J. V., "Lactone Polymerization and Polymer Properties," J. Macromol. Sci. Chem., vol. A6, pp. 1109-1144 (1972).
Cowsar, D., Tice, T. R., Gilley, R. M. and English, J. P., "[8]Poly(lactide-co-glycolide) Microcapsules for Controlled Release of Steroids," Methods in Enzymology, vol. 112, pp. 101-116 (1985).
D'Souza, S. E., Ginsberg, M. H., Lam, S. C. T. and Plow, E. F., "Chemical Cross-Linking of Arginyl-Glycyl-Aspartic Acid Peptides to an Adhesion Receptor on Platelets," The Journal of Biological Chemistry, vol. 263, pp. 3943-3951 (1988).
Dunsing, R. and Kricheldorf, H. R., "Polylactones; 5, Polymerization of L,L-Lactide by Means of Magnesium Salts," Polymer Bulletin, vol. 14, pp. 491-495 (1985).
Gilding, D. K., Reed, A. M. and Askill, I. N., "Calibration in Gel Permeation Chromatography: Primary, Universal and Empirical Methods," Polymer, vol. 22, pp. 505-512 (1981).
Greene, T. W., "Protective Groups in Organic Synthesis," pp. 239-241, John Wiley and Sons, Inc., New York (1981), Greenstein, J. P. and Winitz, M., Chemistry of the Amino Acids, vol. 2, pp. 887-901, John Wiley and Sons, Inc., New York (1961).
Helder, J. et al., "Synthesis of Poly [Oxyethylidenecarbonylimino-(2-Oxoethylene)][Poly(Glycine-D,L-Lactic Acid)]by Ring Opening Polymerization," Markromol. Chem., Rapd Commun., vol. 6, pp. 9-14 (1985).
Helder, J., and Feiien, J., "Copolymers of D,L-Lactic Acid and Glycine," Makrom. Chem. Rapid Commun., vol. 7, pp. 193-198 (1986).
Hoare, D. G. and Koshland, D. E. Jr., "A Method for the Quantitative Modification and Estimation of Carboxylic Acid Groups in Proteins," J. Biol. Chem., vol. 242, pp. 2447-2453 (1967).
Ivin, J. K. and Saegusa, T., eds., "Ring Opening Polymerization," vol.s 1-3, Elseveir Applied Science Publishers, New York (1984).
Kohn, F. E., Ommen, J. G. van and Feijen, J., "The Mechanism of the Ring-Opening Polymerization of Lactide and Glycolide," Eur. Polym. J., vol. 19, pp. 1081-1088 (1983).
Kohn, F. E., Van Den Berg, J. W. A., and Van De Ridder, G., "The Ring-Opening Polymerization of D,L-Lactide in the Melt Initiated with Tetraphenyltin," J. Applied Polymer Sci., vol. 29, pp. 4265-4277 (1984).
Kricheldorf, H. R., Jonte, J. M. and Berl, M., "Polylactones: 3, Copolymerization of Glycolide with L,L-Lactide and other Lactones," Makromol. Chem. Suppl., vol. 12, pp. 25-38 (1985).
Kricheldorf, H. R. and Sumbel, M., "Polylactones-18, Polymerization of L,L-Lactide with Sn(II) and Sn(IV) Halogenides," Eur. Polym. J., vol. 25, pp. 585-591 (1989).
Leenslag, J. W. and Pennings, A. J., "Synthesis of High Molecular Weight Poly(L-Lactide) Initiated with Tin 2-Ethylhexanoate," Makromol. Chem., vol. 188, pp. 1809-1814 (1987).
Mooney, D., et al., "Switching Between Growth and Differential in Hepatocytes: Control by Extracellular Matrix," J. Cell. Biol., Thirteenth Annual Meeting, abstracts, pp. 816.
Naravanan, S., et al., "Glutaraldehyde-P, a Stable, Reactive Aldehyde Matrix for Affinity Chromatography," Analytical Biochemistry, vol. 188, pp. 278-284 (1990).
Samyn, C. and Van Beylan, M., "Polydepsipeptides: Ring-Opening Polymerization of 3-Methyl-2,5-Morpholinedione, 3,6-Dimethyl-2,5-Morpholinedione and Copolymerization Thereof With D,L-Lactide," Makromol. Chem., Macromol Symp., 19, 225-234 (1988).
Sawan, S. P. and Barry, J. J., "Quantitation of Poly (d,I-Lactic Acid) Degradation Products by HPLC," Polymer Preprints, vol. 29, pp. 299-300 (1988).
Sheehan, J. C., Preston, J., and Cruickshank, P. A., "A Rapid Synthesis of Oligopeptide Derivatives Without Isolation of Intermediates," J. Am. Chem. Soc., vol. 87, pp. 2492-2493 (1965).
Staros, J. V., "H-Hydroxysulfosuccinimide Active Esters: Bis(N-hydroxysulfosuccinimide) Esters of Two Dicarboxylic Acids are Hydrophilic, Membrane-Impermeant, Protein Cross-Linkers," Biochemistry, vol. 21, pp. 3950-3955 (1982).
Veld, P. J. A. int, et al., "Synthesis of Alternating Polydepsipeptides by Ring-Opening Polymerization of Morpholine-2,5-Dione Derivatives," Makromol. Chem., vol. 191, 1813-1825 (1990).
Weston, P. D. and Avrameas, S., "Proteins Coupled to Polyacrylamide Beads Using Glutaraldehyde," Biochem. and Biophys. Research Comm., vol. 45, pp. 1574-1580 (1971).
Yamada, H., et al., "Cyclic Peptides: VIII, Synthesis and Tryptic Hydrolysis of Cyclic Depsidipeptides Containing a Lysine Residue," Int. J. Peptide Protein Res., vol. 16, pp. 61-65 (1980).
Yasutake, A., et al., "Cyclic Peptides: VIII. Synthesis and Tryptic Hydrolysis of Cyclic Depsidipeptides Containing a Lysine Residue,"0 Int. J. Peptide Protein Res., vol. 16, pp. 61-65 (1980).
Yonezawa, N., Toda, F. and Hasegawa, M., "Synthesis of Polydepsipeptides: Ring-opening Polymerization of 6-Isopropylmorphiline-2,5-dione and 6-Isopropyl-4-Methylmorpholine-2,5- dione," Makromol. Chem., Rapid Commun., vol. 6, pp. 607-611 (1985).
Arnold, S., and Lenz, R., "Synthesis of Stereoregular Poly(alkyl Malolactonates)," Makromol. Chem. Macromol. Symp. vol. 6, pp. 285-303 (1986).
Barrera, D. et al., "Poly (lactic acid-co-Lysine); A new material for organ regeneration," AIChE Abstract (Nov. 18, 1991).
Boustta, M., et al., "New Functional

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Biodegradable polymers for cell transplantation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Biodegradable polymers for cell transplantation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biodegradable polymers for cell transplantation will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1149797

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.