Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – From phosphorus-containing reactant
Patent
1998-04-02
2000-12-26
Merriam, Andrew E. C.
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
From phosphorus-containing reactant
523111, 523113, 528352, 528400, 424 7837, 424426, 424486, 623 1, 623 12, 623 16C, 525538, C08G 7904, A61K 3180
Patent
active
061661732
ABSTRACT:
Biodegradable polymers are described comprising the recurring monomeric units shown in formula I or II: wherein X is --O-- or --NR'--, where R' is H or alkyl; L is a branched or straight chain aliphatic group having from 1-20 carbon atoms; M.sub.1 and M.sub.2 are each independently (1) a branched or straight chain aliphatic group having from 1-20 carbon atoms; or (2) a branched or straight chain, oxy-, carboxy- or amino-aliphatic group having from 1-20 carbon atoms; Y is --O--, --S-- or --NR'--, where R' is H or alkyl; R is H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; the molar ratio of x:y is about 1; the molar ratio n:(x or y) is between about 200:1 and 1:200; and the molar ratio q:r is between about 1:99 and 99:1; wherein said biodegradable polymer is biocompatible before and upon biodegradat.
Processes for preparing the polymers, compositions containing the polymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the polymers, are also described.
REFERENCES:
patent: 3442982 (1969-05-01), Friedman
patent: 5256765 (1993-10-01), Leong
patent: 5530093 (1996-06-01), Engelhardt et al.
Petula et al., "High-molecular-weight Poly(alkylene Phosphonate)s by Condensation of Dialkylphosphonates with Diols", Makromol. Chem., 191:3, 671-80 (1990).
Heller et al., "Release of Norethindrone from Poly(Ortho Esters)", Polymer Engineering Sci., 21:11, 727-31 (1981).
English James P.
Leong Kam W.
Mao Hai-quan
Zhao Zhong
Guilford Pharmaceuticals Inc.
Johns Hopkins University
Merriam Andrew E. C.
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