Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1986-10-02
1989-09-05
Moskowitz, Margaret
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424426, 424457, 424458, 424460, 424461, 424 88, 424 89, 424 92, 424 78, 514 2, 514 8, 514 23, 514885, 514953, 514963, 514964, 514965, 525 541, A61K 900, A61K 952, A61J 300
Patent
active
048637351
ABSTRACT:
An antigen delivery system utilizing a biodegradable polymer with good mechanical properties in combination with a material stimulating the immune system. The material having adjuvant activity may be polymer degradation products or an adjuvant which is contained within or bound to the polymer. In one embodiment, the polymer is formed from tyrosine dipeptides. Poly(CTTH-iminocarbonate) is a preferred tyrosine dipeptide polymer for constructing implantable delivery systems for antigenic material. The polymer is not an adjuvant in itself but degrades into products which stimulate the immune system. The tyrosine dipeptide can also be used as a conventional adjuvant. The advantages of the system are that a polymer can be used to form a biodegradable integral structure which is useful as both an implantable source of an antigen or other biologically active compound and as a control means for the rate of release of the biologically active compound, wherein the result is sustained, relatively constant delivery of antigen with simultaneous stimulation of the immune response.
REFERENCES:
patent: 3773737 (1973-11-01), Goodman et al.
patent: 4225581 (1989-09-01), Kreuter et al.
patent: 4258029 (1981-03-01), Maloney et al.
patent: 4385169 (1983-05-01), Kato et al.
patent: 4428932 (1984-01-01), Overell
patent: 4450150 (1984-05-01), Sidmon
patent: 4551478 (1985-04-01), Nowinski et al.
patent: 4605413 (1986-08-01), Urry et al.
patent: 4675381 (1987-06-01), Bichon
patent: 4753804 (1988-06-01), Iaccheri et al.
Mozes et al, PNAS 77(8) 1980, pp. 4933-4937.
Preis and Langer, J. Immunol. Methods, 28, 193-197, (1979).
Langer, Methods Enzymol., 73, 57-75 (1981).
Niemi, et al., Lab. Animal Sci., 35, 609-612 (1985).
Wheeler, et al., Int. Archs Allergy Appl. Immun., 69, 113-119 (1982).
Miller and Tees, Clinical Allergy, 4, 49-55 (1974).
Wheeler, et al., Int. Archs Allergy Appl. Immun., 75, 294-299 (1984).
Penney, et al., J. Biol. Stand., 13, 43-52 (1985).
Fox James G.
Kohn Joachim B.
Langer Robert S.
Niemi Steven M.
Draper Garnette D.
Massachusetts Institute of Technology
Moskowitz Margaret
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