Biodegradable polymer networks for use in orthopedic and dental

Details Biodegradable polymer networks for use in orthopedic and dental Biodegradable polymer networks for use in orthopedic and dental

1996-02-20

1999-05-11

Smith, Lynette F.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424422, 424427, 424428, 424484, 424486, 424487, 5147726, 522 1, 522 6, 522 33, 522 38, 522 40, 522 43, 522 60, 523114, A61F2/28;2/30

Patent

active

059025999

ABSTRACT:
Biodegradable polymer networks are provided which are useful in a variety of dental and orthopedic applications. The biodegradable polymer networks can be formed in one embodiment by polymerizing anhydride prepolymers including crosslinkable groups, such as unsaturated moieties. The anhydride prepolymers can be crosslinked, for example in a photopolymerization reaction by irradiation of the prepolymer with light in the presence of a free radical initiator. Suitable anhydride prepolymers include dianhydrides of a dicarboxylic acid and a carboxylic acid molecule comprising a crosslinkable group. For example, methacrylic acid dianhydrides of monomers or oligomers of a diacid such as sebacic acid or 1,3-bis(p-carboxyphenoxy)-hexane can be used. The anhydride prepolymers can be applied in vivo to a site where an orthopedic implant is needed, and then may be crosslinked, for example, by irradiation with U.V. light, to form a biodegradable implant such as a rods, pin or plate. The implants advantageously provide mechanical support and also are capable of slow surface degradation to permit bone ingrowth.

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