Biodegradable polyacetals

Details Biodegradable polyacetals Biodegradable polyacetals

2005-04-12

2005-04-12

Acquah, Samuel A. (Department: 1711)

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

C528S332000, C528S363000, C528S364000, C528S376000, C528S392000, C528S422000, C528S425000, C525S535000, C525S540000, C514S579000, C514S609000, C514S613000, C514S716000, C514S722000, C514S723000, C424S178100, C424S001530, C424S179100, C530S391500, C530S402000

Reexamination Certificate

active

06878374

ABSTRACT:
A polymer comprising recurring units represented by formula (I):wherein X is selected from the group consisting of C(O)OR1, C(O)SR1, C(O)NR1R2, and VZ, where R1and R2are each individually selected from the group consisting of hydrogen, C1to C10alkyl, and C6to C10aryl, where V is a labile linker group, and where Z is selected from the group consisting of poly(ethyleneimine), poly(propyleneimine), poly(lysine), PAMAM dendrimer, octaamine dendrimer, and hexadecaamine dendrimer; and wherein Y is selected from the group consisting of —(CH2)2—, —(CH2)2—O—(CH2)2—, —(CH2)2—O—(CH2)2—, and —(CH2)3—NHC(O)—(CH2)6—C(O)NH—(CH2)3— is useful in nucleic acid delivery applications. Polyacetals of the formula (I) are preferably made by reacting appropriate diols and divinyl ethers. In preferred embodiments, complexes formed between polyacetals of the formula (I) and polynucleotides are useful as transfection reagents.

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