Biodegradable polyacetal polymers and methods for their formatio

Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...

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528425, 527300, 527305, 525398, 525400, 525472, 525509, 522178, C08L 6102

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058639900

ABSTRACT:
The present invention relates to biodegradable biocompatible polyacetals, methods for their preparation, and methods for treating mammals by administration of biodegradable biocompatible polyacetals. A method for forming the biodegradable biocompatible polyacetals combines a glycol-specific oxidizing agent with a polysaccharide to form an aldehyde intermediate which is combined with a reducing agent to form the biodegradable biocompatible polyacetal. The resultant biodegradable biocompatible polyacetals can be chemically modified to incorporate additional hydrophilic moieties. A method for treating mammals includes the administration of the biodegradable biocompatible polyacetal in which biologically active compounds or diagnostic labels can be disposed.

REFERENCES:
patent: 4024073 (1977-05-01), Shimizu et al.
patent: 4303767 (1981-12-01), Heller et al.
patent: 4549010 (1985-10-01), Sparer et al.
patent: 4713441 (1987-12-01), Heller et al.
patent: 5202434 (1993-04-01), Wilkening
patent: 5359071 (1994-10-01), Durette et al.
patent: 5460752 (1995-10-01), Fredj et al.
Jedlinski, Z. et al., "Investigations on the Stereochemistry and Polymerization of the 1, 3-Dioxolane Derivatives," Polymer Bulletin, 2: 599-605 (1980).
Kataoka, K. et al., "Block Copolymer Micelles as Vehicles for Delivery of Anti-Cancer Drugs," Paper Presented at the Sixth International Symposium on Recent Advances In Drug Delivery Systems, (1993).
Bogdanov, Jr., A.A. et al., "A New Macromolecule as a Contrast Agent for MR Angiography: Preparation, Properties, and Animal Studies," Radiology, 187: 701-706 (1993).
Drobchenko, S.N. et al., "An Investigation of the Structure of Periodate-Oxidised Dextran," Carbohydrate Research, 241: 189-199 (1993).
Gibas, M., Initiation of the Polymerization of 1, 3-dioxolane with 2, 4, 5-trisubstituted 1, 3-dioxolan-2-ylium salts, 2.sup.a), Makromol. Chem., 188:675-681 (1987).
Heller, J. et al., "Preparation of Polyacetals by the Reactions of Divinyl Ethers and Polyos," Journal of Polymer Science: Polymer Letters Edition, 18:293-297 (1980).
Jeanes, A. and Seymour, F.R., "The .alpha.-D-Glucopyranosidic Linages of Dextrans: Comparison of Percentages from Structural Analysis by Periodate Oxidation and by Methylation," Carbohydrate Research, 74:31-40 (1979).
Richards, E.L., "Imidazoles from the Reaction of Periodate-Oxidized Polysaccharides with Ammonia," Aust. J. Chem., 23:1033-1037 (1970).
Moghimi, S.M. et al., "Surface Engineered Nanospheres with Enhanced Drainage into Lymphatics and Uptake by Macrophages of the Regional Lymph Nodes," FEBS Letters, 344:25-30 (1994).
Torchilin, V.P. and Papisov, M.I., "Why Do Polyethylene Glycol-Coated Lipsomes Circulate So Long?," Journal of Liposome Research, 4(1): 725-739 (1994).
Torchilin, V.P. et al., "Poly (ethylene glycol) on the Liposome Surface: On the Mechanism of Polymer-Coated Liposome Longevity," Biochimica et Biophysica Acta, 1195:11-20 (1994).

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