Biodegradable polyacetal polymers and methods for their formatio

Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active...

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528230, 528232, 528239, 525400, 525401, 525403, 525405, 525417, 514693, 514696, A61K 3174

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059583983

ABSTRACT:
The present invention relates to biodegradable biocompatible polyacetals, methods for their preparation, and methods for treating mammals by administration of biodegradable biocompatible polyacetals. A method for forming the biodegradable biocompatible polyacetals combines a glycol-specific oxidizing agent with a polysaccharide to form an aldehyde intermediate which is combined with a reducing agent to form the biodegradable biocompatible polyacetal. The resultant biodegradable biocompatible polyacetals can be chemically modified to incorporate additional hydrophilic moieties. A method for treating mammals includes the administration of the biodegradable biocompatible polyacetal in which biologically active compounds or diagnostic labels can be disposed.

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