Biodegradable poly (amino acid)s, derivatized amino acid polymer

Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – From carboxylic acid or derivative thereof

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Details

528328, C08G 6344, C08G 6900, C08G 6944

Patent

active

059291982

ABSTRACT:
New and improved polyamino acid polymers and derivatized polyamino acid polymers are provided. Relatively high molecular weight poly(succinimides) are prepared by solid phase polymerization of aspartic acid or glutamic acid in the presence of a super phosphoric acid catalyst. The poly(succinimides) may be hydrolyzed to provide biodegradable polyaspartic acid or polyglutamic acid homopolymer having weight average molecular weights.gtoreq.70,000. Higher molecular weight, water soluble, cross-linked polyamino acid polymers and gels are also provided. In a preferred embodiment, the poly(succinimides) are derivatized in aqueous media to provide storage stable, substantially linear, biodegradable polyamino acid polymers having pendant hydroxyl, ether, hydroxyalkylaminoalkyl, hydroxyalkoxyalkyl, carboxyl, sulfonoalkyl and/or phosphonoalkyl functionalities. The polymers are useful as chelants in various water treatment applications.

REFERENCES:
patent: 5531934 (1996-07-01), Freeman et al.
J. Kalal et al., "Affinity Chromatography and AffinityTherapy", Affinity Chromatography and Techniques TCJ Gribanu, J. Visser and R.J. Nivard (Editors) Copyright 1982 Elsevier Scientific Publishing Company, Amsterdam, The Netherlands pp. 365-374.

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