Biodegradable microspheres as a carrier for macromolecules

Details Biodegradable microspheres as a carrier for macromolecules Biodegradable microspheres as a carrier for macromolecules

1990-01-09

1992-11-03

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424486, 424499, 424501, 42840222, 514 2, 514963, 514965, 514885, A61K 914, A61K 950, A61K 952, B01J 1318

Patent

active

051607450

ABSTRACT:
A method for preparing biodegradable microspheres having a three-dimensional network in which biologically active macromolecular agents are physically entrapped therein. The microsphere is able to degrade and release the macromolecular agent at a controlled rate. The method involves emulsifying a vinyl derivative of a biodegradable hydrophilic polymer, a water-soluble monovinyl monomer and a biologically active macromolecule in water, and copolymerizing the biodegradable hydrophilic polymer and the water-soluble monovinyl monomer such that the biologically active macromolecule is entrapped therein.

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