Biodegradable microcapsules having walls composed of crosslinked

Details Biodegradable microcapsules having walls composed of crosslinked Biodegradable microcapsules having walls composed of crosslinked

1993-06-08

1995-03-07

Kishore, G. S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424489, 42840224, A61K 950

Patent

active

053956206

ABSTRACT:
The invention relates to microcapsules with a mixed wall of crosslinked atelocollagen and polyholosides, for example glycosaminoglycans, and to processes for the manufacture of the said microcapsules. According to the invention, the microcapsules comprise a mixed wall of crosslinked atelocollagen and polyholosides, for example glycosaminoglycans, the proportion of polyholosides, for example glycosaminoglycans, relative to the atelocollagen preferably being between 18 and 50% by weight. These microcapsules can be manufactured either by a process involving interfacial crosslinking or by the extrusion of a laminar flow which is broken up by vibrations into individual droplets, which fall into a crosslinking bath. These microcapsules are biocompatible by virtue of the presence of atelocollagen, which has most of the advantageous properties of collagen, namely a very low antigenicity and a perfect biodegradability. They are therefore particularly suitable for the manufacture of cosmetic, pharmaceutical or food compositions.

REFERENCES:
patent: 4280954 (1981-07-01), Yannas et al.
patent: 4780321 (1988-10-01), Levy et al.
patent: 4931546 (1990-06-01), Tardy et al.
patent: 5011692 (1991-04-01), Fujioka
patent: 5169631 (1992-12-01), Rase
"Utilising Collagen in Drug Formulation", Manufacturing Chemist, vol. 57, No. 9, Sep. 1986, pp. 64-65, 67, London, Great Britain.

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