Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure
Patent
1989-07-10
1991-05-28
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Molecular bilayer structure
424 5, 424486, 424487, 514951, 128632, A61K 4904, A61K 914, A61B 500
Patent
active
050193708
ABSTRACT:
A biodegradable, low biological toxicity, particulate radiographic contrast medium comprises biodegradable polymeric spheres of average molecular weight average diameter about 10-1,000 nm or about 0.01-1.0 micron carrying in at least radiographic contrasting amount of a radiographically opaque element.
A method of obtaining a tomographic image of the body portion of a subject comprises administering to the subject a radiographically-detectable amount of the biodegradable, low-toxicity radiographic medium of claim 1; allowing for the spheres to be taken-up by the body portion; and X-raying an area comprising the body portion.
A method of improving the contrast of a tomographic image of a body portion of a subject comprises administering to the subject a radiographically-detectable amount of the biodegradable, low-toxicity radiographic medium of claim 1; allowing for the spheres to be selectively taken-up by the body portion; and X-raying an area comprising the body portion.
REFERENCES:
patent: 1858142 (1932-05-01), Ellzey
patent: 1984404 (1934-12-01), Ellzey
patent: 4406878 (1983-09-01), DeBoer
patent: 4680171 (1987-07-01), Shell
patent: 4783484 (1988-11-01), Violante et al.
patent: 4804529 (1989-02-01), Bardy et al.
Kreuter, J. 1983, Pharm. Acta Helv. 58(7); 196-209, Evaluation of Nanoparticles as Drug-delivery Systems, I. Preparation Methods.
"Radiographic Contrast Agents", R. E . Miller, M.D. and J. Skucas, M.D., University Park Press.
"Particulate Contrast Media", M. R. Violante et al.
"Computed Tomographic Enhancement of Liver and Spleen in the Dog with Idipamide Ethyl Ester Particulate Suspensions", Violante and Gadeholt.
"Effect of Intraveneously Administered Iodipamide Ethyl Ester Particles on Rat Liver Morphology", Lauteala et al.
Jay Michael J.
Ryo U. Yun
Friedman Stanley J.
University of Kentucky Research Foundation
Wilson Terry L.
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