Biodegradable injectable particles for imaging

Details Biodegradable injectable particles for imaging Biodegradable injectable particles for imaging

1994-03-18

1996-10-15

Azpuru, Carlos

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424489, 424497, 424498, 424502, 424451, 424462, 424 7808, 5147723, 514784, 514963, 42840221, 42840224, 428403, A61K 950, A61K 948, A61K 3174, A61K 4730

Patent

active

055652158

ABSTRACT:
Injectable nanoparticles or microparticles are provided that are not rapidly cleared from the blood stream by the macrophages of the reticuloendothelial system, and that can be modified as necessary to achieve variable release rates or to target specific cells or organs as desired. The terminal hydroxyl group of the poly(alkylene glycol) can be used to covalently attach onto the surface of the injectable particles biologically active molecules, including antibodies targeted to specific cells or organs, or molecules affecting the charge, lipophilicity or hydrophilicity of the particle. The surface of the particle can also be modified by attaching biodegradable polymers of the same structure as those forming the core of the injectable particles. The injectable particles include magnetic particles or radioopaque materials for diagnostic imaging.

REFERENCES:
patent: 4801739 (1989-01-01), Franz et al.
patent: 4904479 (1990-02-01), Illum
Brich, Z. et al., "Branched Ter-Polyesters: Synthesis, Characterization, In Vitro and In Vivo Degradation Behaviour", Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 15:95-96 (1988).
Jedlinski, Zbigniew, et al., "Synthesis of ethylene glycol-L-lactide block copolymers," Makromol. Chem. 194: 1681-1689 (1993).

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