Biodegradable in-situ forming implants and methods of producing

Details Biodegradable in-situ forming implants and methods of producing Biodegradable in-situ forming implants and methods of producing

1988-10-03

1990-07-03

Pellegrino, Stephen C.

Surgery

Controlled release therapeutic device or system

Implanted dynamic device or system

A61K 922

Patent

active

049387634

ABSTRACT:
A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.

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