Biodegradable in-situ forming implants and methods of producing

Details Biodegradable in-situ forming implants and methods of producing Biodegradable in-situ forming implants and methods of producing

1991-12-23

1994-01-11

Michl, Paul R.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Processes of preparing a desired or intentional composition...

424422, 424426, 424 7826, 525411, 525415, 525937, 526320, 526321, 604187, C08L 6700, C08L 6900, C08L 7700, A61F 200

Patent

active

052782026

ABSTRACT:
A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.

REFERENCES:
patent: 3760034 (1973-09-01), Critchfield et al.
patent: 4148871 (1979-04-01), Pitt et al.
patent: 4408023 (1983-10-01), Gould et al.
patent: 4983689 (1991-01-01), Yu
patent: 5077049 (1991-12-01), Dunn et al.

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