Biodegradable in-situ forming implants and methods of producing

Details Biodegradable in-situ forming implants and methods of producing Biodegradable in-situ forming implants and methods of producing

1997-11-07

1999-11-23

Merriam, Andrew C.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Processes of preparing a desired or intentional composition...

523113, 424423, 424426, 604 49, 604 51, 525190, 525411, 525412, 525415, 525439, 525450, A61K 908

Patent

active

059901942

ABSTRACT:
A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.

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