Biodegradable in-situ forming implants and methods of producing

Details Biodegradable in-situ forming implants and methods of producing Biodegradable in-situ forming implants and methods of producing

1994-03-18

1998-04-14

Merriam, Andrew E. C.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Processes of preparing a desired or intentional composition...

523115, 604 51, 604 54, 604 56, 604290, 525408, 525412, 525413, 525937, 424422, 424 7838, 524 96, 524601, A61F 202, A61F 200

Patent

active

057391769

ABSTRACT:
A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.

REFERENCES:
patent: 2155658 (1939-04-01), Herrmann
patent: 3068188 (1962-12-01), Beste
patent: 3218283 (1965-11-01), Miller
patent: 3219527 (1965-11-01), Gurney
patent: 3328246 (1967-06-01), Gottfried
patent: 3463158 (1969-08-01), Schmitt
patent: 3520949 (1970-07-01), Shepherd
patent: 3696811 (1972-10-01), Chen
patent: 3755558 (1973-08-01), Scribner
patent: 3760034 (1973-09-01), Critchfield
patent: 3767784 (1973-10-01), Glick
patent: 3887699 (1975-06-01), Yolles
patent: 3931678 (1976-01-01), O'Sullivan
patent: 3935308 (1976-01-01), Wise
patent: 3939111 (1976-02-01), Schollenberger
patent: 4148871 (1979-04-01), Pitt
patent: 4161948 (1979-07-01), Bichon
patent: 4408023 (1983-10-01), Gould
patent: 4439420 (1984-03-01), Mattei et al.
patent: 4443430 (1984-04-01), Mattei et al.
patent: 4447562 (1984-05-01), Ivani
patent: 4450150 (1984-05-01), Sidman
patent: 4491479 (1985-01-01), Lauchenauer
patent: 4568536 (1986-02-01), Kronenthal
patent: 4570629 (1986-02-01), Widra
patent: 4582640 (1986-04-01), Smestad
patent: 4595713 (1986-06-01), St. John
patent: 4631188 (1986-12-01), Stoy
patent: 4650665 (1987-03-01), Kronenthal
patent: 4663077 (1987-05-01), Rei
patent: 4677139 (1987-06-01), Feinmann
patent: 4702917 (1987-10-01), Schindler
patent: 4715369 (1987-12-01), Suzuki
patent: 4745160 (1988-05-01), Churchill
patent: 4767627 (1988-08-01), Caldwell
patent: 4767861 (1988-08-01), Boulware
patent: 4772470 (1988-09-01), Inoue
patent: 4774227 (1988-09-01), Piez
patent: 4780320 (1988-10-01), Baker
patent: 4793336 (1988-12-01), Wang
patent: 4857602 (1989-08-01), Casey et al.
patent: 4920203 (1990-04-01), Tang
patent: 4938763 (1990-07-01), Dunn et al.
patent: 4981696 (1991-01-01), Loomis
patent: 4983689 (1991-01-01), Yu
patent: 5007940 (1991-04-01), Berg
patent: 5013553 (1991-05-01), Southard
patent: 5077049 (1991-12-01), Dunn et al.
patent: 5278201 (1994-01-01), Dunn et al.
patent: 5278202 (1994-01-01), Dunn et al.
patent: 5286763 (1994-02-01), Gerhart et al.
patent: 5324519 (1994-06-01), Dunn et al.
patent: 5324520 (1994-06-01), Dunn et al.
patent: 5340849 (1994-08-01), Dunn et al.
patent: 5368859 (1994-11-01), Dunn et al.
patent: B14938763 (1995-07-01), Dunn et al.
Encyclopedia of Polymer Science and Engineering, vol. 2, pp. 236-237 (Biodegradable Polymers), John Wiley & Sons, Inc. (1985).
Billmeyer, Textbook of Polymer Science (Third Edition), pp. 390-391, John Wiley & Son, New York (1984).
Gilding, Biodegradable Polymers (Chapter 9), pp. 210-232, Biocompatibility of Clinical Implant Materials, (1976).
Hawley's Condensed Chemical Dictionary (11th Ed.) pp. 224, 555 and 567, Van Nostrand Reinhold Co., N.Y., N.Y., (1987).
Holland, Polymers for Biodegradable Medical Devices, 1. The Potential of Polyesters and Controlled Macromolecular Release Systems, J. of Controlled Release 4: 155-180 (1986).

Affiliated with

Also associated with

Rating

Biodegradable in-situ forming implants and methods of producing does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Biodegradable in-situ forming implants and methods of producing , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biodegradable in-situ forming implants and methods of producing will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-635174