Biodegradable in-situ forming implants and methods of producing

Details Biodegradable in-situ forming implants and methods of producing Biodegradable in-situ forming implants and methods of producing

1995-09-25

1998-03-31

Merriam, Andrew E. C.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Processes of preparing a desired or intentional composition...

523115, 604 49, 604 51, 424422, 424 7838, 524 96, 525413, 525450, A61K 908

Patent

active

057339503

ABSTRACT:
A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.

REFERENCES:
patent: 2155658 (1939-04-01), Herrmann
patent: 3068188 (1962-12-01), Beste
patent: 3218283 (1965-11-01), Miller
patent: 3219527 (1965-11-01), Gurney
patent: 3328246 (1967-06-01), Gottfried
patent: 3463158 (1969-08-01), Schmitt
patent: 3520949 (1970-07-01), Shepherd
patent: 3696811 (1972-10-01), Chen
patent: 3755558 (1973-08-01), Scribner
patent: 3760034 (1973-09-01), Critchfield
patent: 3767784 (1973-10-01), Glick
patent: 3887699 (1975-06-01), Yolles
patent: 3931678 (1976-01-01), O'Sullivan
patent: 3935308 (1976-01-01), Wise
patent: 3939111 (1976-02-01), Schollenberger
patent: 4148871 (1979-04-01), Pitt
patent: 4161948 (1979-07-01), Bichon
patent: 4408023 (1983-10-01), Gould
patent: 4439420 (1984-03-01), Mattei
patent: 4443430 (1984-04-01), Mattei
patent: 4447562 (1984-05-01), Ivani
patent: 4450150 (1984-05-01), Sidman
patent: 4491479 (1985-01-01), Lauchenauer
patent: 4568536 (1986-02-01), Kronenthal
patent: 4570629 (1986-02-01), Widra
patent: 4582640 (1986-04-01), Smestad
patent: 4595713 (1986-06-01), St. John
patent: 4631188 (1986-12-01), Stoy
patent: 4650665 (1987-03-01), Kronenthal
patent: 4663077 (1987-05-01), Rei
patent: 4677139 (1987-06-01), Feinmann
patent: 4702917 (1987-10-01), Schindler
patent: 4715369 (1987-12-01), Suzuki
patent: 4745160 (1988-05-01), Churchill
patent: 4767627 (1988-08-01), Caldwell
patent: 4767861 (1988-08-01), Boulware
patent: 4772470 (1988-09-01), Inoue
patent: 4774227 (1988-09-01), Piez
patent: 4780320 (1988-10-01), Baker
patent: 4793336 (1988-12-01), Wang
patent: 4800219 (1989-01-01), Murdoch et al.
patent: 4804691 (1989-02-01), English et al.
patent: 4920203 (1990-04-01), Tang
patent: 4938763 (1990-07-01), Dunn et al.
patent: 4981696 (1991-01-01), Loomis
patent: 4983689 (1991-01-01), Yu
patent: 5013553 (1991-05-01), Southard
patent: 5077049 (1991-12-01), Dunn et al.
patent: 5278201 (1994-01-01), Dunn et al.
patent: 5278202 (1994-01-01), Dunn et al.
patent: 5286763 (1994-02-01), Gerhart
patent: 5324519 (1994-06-01), Dunn et al.
patent: 5324520 (1994-06-01), Dunn et al.
patent: 5340849 (1994-08-01), Dunn et al.
patent: 5368859 (1994-11-01), Dunn et al.
patent: B14938763 (1995-07-01), Dunn et al.
Encyclopedia of Polymer Science and Engineering, vol. 2, pp. 236-237 (Biodegradable Polymers), John Wiley & Sons, Inc. (1985).
Billmeyer, Textbook of Polymer-Science (Third Edition), pp. 390-391, John Wiley & Son, New York (1984).
Gilding, Biodegradable-Polymers (Chapter 9), pp. 210-232, Biocompatibility of Clinical Implant Materials, (1976).
Hawley's Condensed Chemical Dictionary (11th Ed.) pp. 224, 555 and 567, Van Nostand Reinhold Co., NY, NY, (1987).
Holland, Polymers-for Biodegradable Medical Devices, 1. The Potential of Polyesters and Controlled Macromolecular Release Systems, J. of Controlled Release 4: 155-180 1986).

Affiliated with

Also associated with

Rating

Biodegradable in-situ forming implants and methods of producing does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Biodegradable in-situ forming implants and methods of producing , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biodegradable in-situ forming implants and methods of producing will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-52644