Biodegradable, implantable drug delivery depots, and method for

Details Biodegradable, implantable drug delivery depots, and method for Biodegradable, implantable drug delivery depots, and method for

1981-05-11

1984-05-22

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 14, 424 15, 424 19, 252 6253, 42840221, 604891, A61K 4300, A61K 3724, A61K 906

Patent

active

044501501

ABSTRACT:
An implantable drug deliver depot comprising a hydrophilic poly(glutamic acid-co-ethyl glutamate) structure having one or more substances, e.g., drugs and/or diagnostic agents physically contained therein. The drug or diagnostic agent is released by its permeation of and diffusion through the copolymer structure. The depot may be designed to release the substance or substances at predetermined rates and in predetermined sequence. The copolymer structure ultimately biodegrades to glutamic acid. Among the preferred configurations for the depots are rods and closed-end capsules.

REFERENCES:
patent: 4230685 (1980-10-01), Senyei et al.
patent: 4247406 (1981-01-01), Widder et al.
patent: 4298594 (1981-11-01), Sears et al.
patent: 4351337 (1982-09-01), Sidman
patent: 4356166 (1982-10-01), Peterson et al.
patent: 4357259 (1982-11-01), Senyei et al.
Sidman, K. R. et al., Naltrexone, Research Monograph 28, National Institute on Drug Abuse, (1980), pp. 214-232.
Sidman, K. R. et al., J. Membrane Science, vol. 7, (1980), pp. 277-291.
Sidman, K. R. et al., Biopolymers, vol. 22, (1983), pp. 547-556.

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