Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1995-03-13
1996-02-20
Foelak, Morton
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424426, 623 11, A61F 1300
Patent
active
054926971
ABSTRACT:
A biodegradable implant for placement in nonunion bone fractures as a substitute for bone graft material is provided which is a flat plate or disk having a thickness of between about 1 mm and about 15% of the length of the bone, interconnected micropores, and canals substantially equivalent in size and spacing to naturally-occurring Haversian canals. The implant may additionally comprise additives such as growth factors, including bone morphogenic protein. In a preferred embodiment the implant is formed from a biodegradable polymer such as a polylactic acid-polyglycolic acid copolymer by a gel casting technique followed by solvent extraction to precipitate the implant as a microporous solid.
REFERENCES:
patent: 5290494 (1994-03-01), Coombes et al.
patent: 5397572 (1995-03-01), Coombes et al.
Agrawal Chandra M.
Boyan Barbara D.
Heckman James D.
Board of Regents, Univ. of Texas System
Foelak Morton
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