Surgery – Controlled release therapeutic device or system – Implanted dynamic device or system
Patent
1985-06-11
1986-09-16
Yasko, John D.
Surgery
Controlled release therapeutic device or system
Implanted dynamic device or system
424 19, A61K 922
Patent
active
046120092
ABSTRACT:
The invention pertains to a biodegradable implant formed from a gel completely decomposable in body, which contains the antitumour medical - diamminedichloroplatinum addition compound (cisplatin) and to a method for preparation of this implant.
An object of the invention is a biodegradable implant, wherein a matrix of the said implant is formed by a starch gel containing 0.2 to 2 wt. % NaCl, plasticized by addition of 1 to 30 wt. % of glycerol, suitably shaped, and contains the homogeneously dispersed microcrystalline cisplatin in the amount of 1 to 15 wt. %.
A method for preparation the implant according to the invention consists in a homogeneous mixing of 1 wt. part of a viscous aqueous solution, obtained by dissolution of 0.4 to 4 wt. % NaCl and conversion of 1 to 6 wt. % of starch to a paste by boiling, with 0.1 to 0.8 wt. parts of glycerol, 0.5 to 1 wt. part of starch, and the required amount of microcrystalline cisplatin, deaeration of the mixture, conversion to a gel in a mould determining the final shape of implant by heating in a boiling-water bath, and, eventually, in hardening by soaking in a water-miscible solvent, advantageously in acetone or ethanol.
An advantage of the implant according to the invention consists in a relatively fast release of cisplatin into surroundings, which is desirable with respect to the mechanism of cisplatin action. Another advantage is the degradability of implant to products natural for body, which have not toxicologic nor immunologic importance.
REFERENCES:
patent: 4346709 (1982-08-01), Schmitt
patent: 4351337 (1982-09-01), Sidman
patent: 4450150 (1984-05-01), Sidman
Drobnik Jaroslav
Stepankova Helena
Ceskoslovenska akademie ved
Yasko John D.
LandOfFree
Biodegradable implant and a method for preparation thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Biodegradable implant and a method for preparation thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biodegradable implant and a method for preparation thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1993391