Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices
Patent
1988-08-31
1990-05-15
Robinson, Ellis P.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Matrices
424423, 424426, 424488, 424499, A61K 914
Patent
active
049256777
ABSTRACT:
A biodegradable hydrogen matrix is provided, useful for the controlled release of pharmacologically active agents. The matrix is formed by cross-linking a proteinaceous component and a polysaccharide or mucopolysaccharide, and then loading a selected drug therein. By varying temperature, ionic strength, and the composition of the hydrogel matrix, one can control degradation kinetics, the degree of uptake of a particular pharmacologically active agent, and the overall timed release profile.
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Teisn et al., Heparin Coupled to Albumin, Dextran, & Ficoll: Influence on Blood Coagulation & Platelets and In Vivo Duration, Thrombosis Research (1975).
Davis et al., J. Controlled Release (1987) 4:293-302.
Dickinson et al., J. Biomed. Materials Res. (1981)15:557-589.
Lee, J. Controlled Release (1985) 2:277-288.
Guest Shelly J.
Robinson Ellis P.
TheraTech Inc.
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