Biodegradable foams for cell transplantation

Details Biodegradable foams for cell transplantation Biodegradable foams for cell transplantation

1994-03-28

1997-11-11

Krass, Frederick

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

264 456, 264 458, 264 459, 264 464, 264 466, 264 468, 264 48, 264 53, 264 41, 435246, 4283066, 4283084, 4283155, 623 16, A61F 200

Patent

active

056860919

ABSTRACT:
A structurally rigid biodegradable foam scaffold useful for cell transplantation is provided. The foam can be loaded with nutrients and/or drugs that elute from the foam during transplant to promote growth of the cells. The foam, which features a continuous network of pores, is fabricated using a novel method involving phase separation and consequent expansion upon sublimation of a liquid solvent, preferably naphthalene.

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Learning How To Suppress Cancer Jean Marx, Science, 261:1385-1387, Sep. 10, 1993.
Tissue Engineering by Cell Transplantation Using Degradable Polymer Substrates Cima, et al., Journal of Biomechanical Engineering, 113:143-151, May 1991.
Preparation of poly(glycolic acid) bonded fiber structures for cell attachment and transplantation Mikos, et al., Journal of Biomedical Materials Research, 27:183-189, 1993.

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