Biodegradable cross-linked cationic multi-block copolymers...

Details Biodegradable cross-linked cationic multi-block copolymers... Biodegradable cross-linked cationic multi-block copolymers...

2004-11-03

2011-11-15

Seidleck, James J (Department: 1765)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

C528S310000, C528S332000

Reexamination Certificate

active

08057821

ABSTRACT:
A biodegradable cross-linked cationic multi-block copolymer of linear polyethylenimine (LPEI) wherein the LPEI blocks are linked together by hydrophilic linkers with a biodegradable disulfide bond and methods of making thereof. The biodegradable cross-linked cationic multi-block copolymer may also contain pendant functional moieties which are preferably receptor ligands, membrane permeating agents, endosomolytic agents, nuclear localization sequences, pH sensitive endosomolytic peptides, chromogenic or fluorescent dyes.

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