Biodegradable copolymer for medical application

Details Biodegradable copolymer for medical application Biodegradable copolymer for medical application

1994-02-07

1995-12-19

Buttner, David

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

525411, 525413, 528301, 528354, C08G 6508, C08G 6308, C08G 63672, C08G 6360

Patent

active

054769094

ABSTRACT:
The present invention relates to a triblock(ABA) copolymer used for medical application essentially consisting of: PLA, PGA, or PLA/PGA as hydrophobic block(A), biodegradable PEO derivatives synthesized by PEOs less than 4,000 molecular weight by the ester linkage among them as hydrophilic block (B). The present invention also provides a triblock copolymer easily degradable to the compounds less than M.W. 4,000 in order to excrete through the human kidney, which enables its medical application. Furthermore, using the triblock copolymer of the present invention, the improved hydrogel materials with broad biochemical applications can be provided due to its biodegradable and thermoplastic properties.

REFERENCES:
patent: 4452973 (1984-06-01), Casey
patent: 4716203 (1987-12-01), Casey et al.
patent: 4942035 (1990-07-01), Churchill et al.
"Grant & Hackh's Chemical Dictionary" p. 461, 5th Edition.
Journal Of Polymer Science: Part A: Polymer Chemistry, vol. 27, 2151-2159 (1989), K. J. Zhu et al.: Super Microcapsules (SMC). I. Preparation and Characterization of Star Polyethylene Oxide (PEO)-Polylactide (PLA) Copolymers.
Journal Of Applied Polymer Science, vol. 39, 1-9 (1990), K. J. Zhu et al.: Preparation, Characterization, and Properties of Polylactide (PLA)-Poly(ethylene Glycol) (PEG) Copolymers: A Potential Drug Carrier.

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