Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Polymer from ethylenic monomers only
Patent
1996-12-20
2000-03-28
Webman, Edward J.
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Polymer from ethylenic monomers only
424 7837, 5147727, 525415, 528354, 528357, 528359, 528380, 530815, 530816, A61K 31765, A61K 4734, C08G 6308
Patent
active
060428201
ABSTRACT:
Copolymers designed for use as particulate carriers containing functionalizable amino subunits for coupling with targeting ligand are described. The copolymers are polyesters composed of .alpha.-hydroxy acid subunits such as D, L-lactide and .alpha.-amino acid subunits such as serine or in the preferred embodiment, terpolymers of D,L-lactide and glycolide and .alpha.-amino acid subunits such as serine. Stable vaccine preparations useful as delayed release formulations containing antigen(s) or antigen(s) and co-adjuvants encapsulated within or physically mixed with ploymeric microparticles are described. The particulate carriers are useful for delivering agents to the immune system of a subject by mucosal or parenteral routes to produce immune responses, including antibody responses.
REFERENCES:
patent: Re30170 (1979-12-01), Goodman et al.
patent: 5399665 (1995-03-01), Barrera et al.
patent: 5593778 (1997-01-01), Kondo et al.
patent: 5625030 (1997-04-01), Williams et al.
Chong Pele
Klein Michel H.
Sokoll Kenneth K.
Connaught Laboratories Limited
Webman Edward J.
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