Biodegradable copolymer as drug delivery matrix comprising polye

Details Biodegradable copolymer as drug delivery matrix comprising polye Biodegradable copolymer as drug delivery matrix comprising polye

1994-05-04

1996-08-20

Krass, Frederick

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

528 65, 528 66, 528 80, 528 81, 528369, 560157, 560158, 560166, C08G 6532

Patent

active

055480357

ABSTRACT:
This invention concerns the thermoplastic, biodegradable and nontoxic block copolymer which is easily degraded and excreted in human body by the hydrolysis of intramolecular ester and amide bond. The structure of present copolymer comprises i) hydrophilic and swellable soft domain consisting of polyethyleneoxide(PEO), and ii) hydrophobic, biodegradable, crystallizable and non-swellable hard domain consisting of polylactide(PLA), polyglycolide(PGA), polylactideglycolide(PLdA) and polycaprolactone(PCL).

REFERENCES:
patent: 4716203 (1987-12-01), Casey et al.
patent: 4942035 (1990-07-01), Churchill et al.
patent: 4963638 (1990-10-01), Pezos et al.
Journal of Polymer Science, Part A: Polymer Chemistry, vol. 27, 2151-2159 (1989): K. J. Zhu, et al.; Super Microcapsules (SMC). Preparation and Characterization of Star Polyethylene Oxide (PEO) --Polylactide (PLA) Copolymers.
Journal of Applied Polymer Science, vol. 39, 1-9 (1990), K. J. Zhu, et al.; Preparation, Characterization, and Properties of Polylactide (PLA)--Poly(ethylene Glycol) (PEG) Copolymers: A Potential Drug Carrier.
Journal of Applied Polymer Science, vol. 50, 1391-1396 (1993), David Shiaw-Guang Hu et al.: Inhibition of Bovine Serum Albumin Adsoprtion by Poly(ethylene glycol) Soft Segment in Biodegradable Poly(ethylene glycol)/Poly(L-lactide) Copolymers.
Journal of Applied Polymer Science, vol. 51, 473-482 (1994); David Shiaw-Guang Hu et al.; Structural Analysis and Degradation Behavior in Polyethylene Glycol/Poly(L-Lactide) Copolymers.

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