Biodegradable coating with inhibitory properties for application

Details Biodegradable coating with inhibitory properties for application Biodegradable coating with inhibitory properties for application

1997-02-10

1998-08-04

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

523112, 6048901, 6048911, 424400, 427 224, 427 225, 427 226, 427 23, 427 231, 623 1, 623 6, 623 11, 623 66, 606154, A61F 200

Patent

active

057889791

ABSTRACT:
A method is disclosed for coating a biomaterial to be placed in contact with a patient's blood flow to inhibit blood coagulation from adhering to the biomaterial that would otherwise result from such contact. A biodegradable material of liquid state compatible with the blood and tissue of the human body is prepared, and an anti-coagulant drug is incorporated into the liquid state of the biodegradable material to form a liquid coating material. The liquid coating material is adhesively applied to a surface of the biomaterial in a substantially continuous overlying layer having a formulation, pattern and thickness selected according to the period of time over which the coating material is to perform its anti-coagulant action. Thereafter the coating material is dried to a layer thickness less than about 100 microns for continuous disintegration thereof as a function of time when the layer is in contact with flowing blood. The method is utilized in an exemplary embodiment in which the biomaterial is a vascular stent.

REFERENCES:
patent: 3663288 (1972-05-01), Miller
patent: 5019096 (1991-05-01), Fox et al.
patent: 5464450 (1995-11-01), Buscemi et al.

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