Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1992-03-13
1995-07-04
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424468, 424476, 424497, A61F 200
Patent
active
054298229
ABSTRACT:
A biodegradable polymeric multiphasic release system of one or more biodegradable bursting units capable of delivering biologically active substances in a burst or pulse at predetermined times and a method for constructing those units is disclosed. The individual bursting units of the system may take the form of a biodegradable, membrane coated capsule surrounding a core material which may include an active agent. The membrane ruptures after a predetermined time upon exposure to water or bodily, or other aqueous environmental fluids. The bursting units may be used in any situation in which a controlled pulsed release of an active substance is desired. The predetermined time release of each bursting unit is controlled by the composition of the core material, the initial radius and wall thickness of the membrane and the porosity of the membrane. The core material may also contain a chemical composition which generates gas as fluid is drawn into the bursting unit thus adding an additional design variable for predetermining bursts.
REFERENCES:
patent: 3952741 (1976-04-01), Baker
patent: 4147767 (1979-04-01), Yapel, Jr.
patent: 4177256 (1979-12-01), Michaels et al.
patent: 4344929 (1982-08-01), Bonsen et al.
patent: 4348387 (1982-09-01), Brownlee et al.
patent: 4351337 (1982-09-01), Sidman
patent: 4439196 (1984-03-01), Higuchi
patent: 4450150 (1984-05-01), Sidman
patent: 4469681 (1984-09-01), Brownlee et al.
patent: 4500337 (1985-02-01), Young et al.
patent: 4564364 (1986-01-01), Zaffaroni et al.
patent: 4568559 (1986-02-01), Nuwayser et al.
patent: 4576604 (1986-03-01), Guittard et al.
patent: 4585652 (1986-04-01), Miller et al.
patent: 4590062 (1986-05-01), Jang
patent: 4591496 (1986-05-01), Cohen et al.
patent: 4623588 (1986-11-01), Nuwayser et al.
patent: 4631190 (1986-12-01), Shen et al.
patent: 4673565 (1987-06-01), Di Luccio et al.
patent: 4698264 (1987-10-01), Steinke
patent: 4717566 (1988-01-01), Eckenhoff et al.
patent: 4722898 (1988-02-01), Errede et al.
patent: 4726951 (1988-02-01), Panoz et al.
patent: 4761289 (1988-08-01), Shalati
patent: 4767628 (1988-08-01), Hutchinson
patent: 4789516 (1988-12-01), Lim
patent: 4810501 (1989-03-01), Ghebre-Sellassi et al.
patent: 4822339 (1989-04-01), Tran
patent: 4828857 (1989-05-01), Sharma et al.
patent: 4837032 (1989-06-01), Ortega
patent: 4847093 (1989-07-01), Ayer et al.
patent: 4863736 (1989-09-01), Azain
patent: 5091185 (1992-02-01), Castillo
patent: 5100669 (1992-03-01), Hyon
patent: 5153002 (1992-10-01), McMullen
Augenstein Don C.
Gresser Joseph D.
Jimoh Abdul G.
Kuethe Dean O.
Trantolo Debra J.
Benston, Jr. William E.
Cambridge Scientific, Inc.
Page Thurman K.
LandOfFree
Biodegradable bursting release system does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Biodegradable bursting release system, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biodegradable bursting release system will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-758660