Biodegradable, anionic polymers derived from the amino acid L-ty

Details Biodegradable, anionic polymers derived from the amino acid L-ty Biodegradable, anionic polymers derived from the amino acid L-ty

1998-04-07

2000-09-19

Coggins, Wynn Wood

Surgery

Means for introducing or removing material from body for...

Treating material introduced into or removed from body...

604175, 6048911, 623 11, 528176, 528182, A61M 3100

Patent

active

061204919

ABSTRACT:
A polymer with a hydrolytically labile backbone and having the structure: ##STR1## wherein R.sub.9 is an alkyl, aryl or alkylaryl group with up to 18 carbon atoms having a pendent carboxylic acid group or the benzyl ester thereof;
R.sub.12 is an alkyl, aryl or alkylaryl group with up to 18 carbon atoms having a pendent carboxylic acid ester group selected from straight and branched alkyl and alkylaryl esters containing up to 18 carbon atoms and ester derivatives of biologically and pharmaceutically active compounds covalently bonded thereto, provided that the ester group is not a benzyl group or a group that is removed by hydrogenolysis;
each R.sub.7 is independently an alkylene group containing up to four carbon atoms;
A is selected from: ##STR2## wherein R.sub.8 is selected from saturated and unsaturated, substituted and unsubstituted alkyl, aryl and alkylaryl groups containing up to 18 carbon atoms;
k is between about 5 and about 3,000; and
x and f independently range from zero to less that one.

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patent: 5658995 (1997-08-01), Kohn et al.
patent: 5670602 (1997-09-01), Kohn et al.

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