Drug – bio-affecting and body treating compositions – Designated organic nonactive ingredient containing other... – Carboxylic acid ester
Patent
1988-06-01
1990-12-25
Shippen, Michael L.
Drug, bio-affecting and body treating compositions
Designated organic nonactive ingredient containing other...
Carboxylic acid ester
514420, 514946, 514947, 544175, 544399, 546248, 548573, 560155, A61K 4700
Patent
active
049803786
ABSTRACT:
Biodegradable absorption enhancers, especially useful in pharmaceutical formulations, are compounds having the formula ##STR1## wherein R is hydrogen, C.sub.1 -C.sub.7 alkyl, benzyl or 4-hydroxybenzyl; n is a whole number from 4 to 18 inclusive; R.sub.1 and R.sub.2 are independently selected from hydrogen and C.sub.1 -C.sub.7 alkyl, or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached are combined to form a substituted or unsubstituted heterocycloalkyl radical having a total of 5 to 7 ring atoms, optionally including a hetero ring atom selected from oxygen, sulfur and nitrogen in addition to the indicated nitrogen atom, the substituents when present being one to three C.sub.1 -C.sub.7 alkyl radicals, which may be the same or different; and R.sub.3 and R.sub.4 are independently selected from hydrogen, methyl and ethyl.
REFERENCES:
patent: 2135641 (1938-11-01), Jacobson
patent: 2290174 (1942-07-01), Epstein
patent: 2293026 (1942-08-01), Day
patent: 2293034 (1942-08-01), Moore
patent: 3899585 (1975-08-01), Misato
patent: 4032325 (1977-06-01), Kida
patent: 4732892 (1988-03-01), Sarpotdar
patent: 4822773 (1989-04-01), Alexander
Nishiahta Toshiaki
Rytting Joseph H.
Wong Ooi
Odontex, Inc.
Shippen Michael L.
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