Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Reexamination Certificate
2003-12-16
2008-08-05
Jones, Dameron L. (Department: 1618)
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
C424S001110, C424S001650, C424S001490, C424S001690, C540S450000
Reexamination Certificate
active
07407645
ABSTRACT:
The present invention is directed to bioconjugates of complexes represented by the formula:wherein R, R′, R1, R′1, R2, R′2, R3, R′3, R4, R′4, R5, R′5, R6, R′6, R7, R′7, R8, R′8, R9, R′9, M, X, Y, Z and n are defined herein for use as contrast agents in diagnostic imaging.
REFERENCES:
patent: 3930867 (1976-01-01), Bigelow
patent: 4001212 (1977-01-01), Richman
patent: 4647447 (1987-03-01), Gries et al.
patent: 4702998 (1987-10-01), Tanaka et al.
patent: 4749560 (1988-06-01), Elgavish
patent: 4952289 (1990-08-01), Ciccone et al.
patent: 5096724 (1992-03-01), Zenner et al.
patent: 5162109 (1992-11-01), Rajagopalan et al.
patent: 5322681 (1994-06-01), Klaveness
patent: 5772982 (1998-06-01), Coward
patent: 5874421 (1999-02-01), Riley et al.
patent: 6084093 (2000-07-01), Riley et al.
patent: 6204259 (2001-03-01), Riley et al.
patent: 6214817 (2001-04-01), Riley et al.
patent: 6525041 (2003-02-01), Neumann et al.
patent: 0281463 (1988-09-01), None
patent: 0287465 (1988-10-01), None
patent: 0296522 (1988-12-01), None
patent: 0374929 (1989-12-01), None
patent: 0391766 (1990-03-01), None
patent: 0457438 (1991-04-01), None
patent: 0524161 (1993-01-01), None
patent: 0588229 (1994-03-01), None
patent: WO 82/04252 (1982-12-01), None
patent: WO 89/11868 (1989-12-01), None
patent: WO 91/10645 (1991-07-01), None
patent: WO 92/08707 (1992-05-01), None
patent: WO 92/21017 (1992-11-01), None
patent: WO 93/05049 (1993-03-01), None
patent: WO 93/06868 (1993-04-01), None
patent: WO 93/12097 (1993-06-01), None
patent: WO 93/14093 (1993-07-01), None
patent: WO 94/15925 (1994-07-01), None
patent: WO 94/26315 (1994-11-01), None
patent: WO 95/10185 (1995-04-01), None
patent: WO 95/28968 (1995-11-01), None
patent: WO 96/39396 (1996-12-01), None
patent: WO 96/40658 (1996-12-01), None
Aston et al., “Asymmetric Synthesis of Highly Functionalized Polyaza Macrocycles via Reduction of Cyclic Peptide Precursors,” Tetrahedron Letters, 1994, pp. 3687-3690, vol. 35.
Brady, “Practical Synthesis of Cyclic Peptides, with an Example of Dependence of Cyclization Yield upon Linear Sequence”, J. Org. Chem., 1979, vol. 44 p. 3101.
Dizio et al., “Progestins-Rhenium Complexes: Metal-Labeled Steriods with High Receptor Binding Affinity, Potential Receptor-Directed Agents for Diagnostic Imaging or Therapy”, Bioconjugate Chemistry, 1991, vol. 2, pp. 353-366.
Dizio et al., “Technetium-and Rhenium-Labeled Progestins: Synthesis, Receptor Binding and In Vivo Distribution of an 11β-Substituted Progestin Labeled with Technetium-99 and Rhenium-186”, Journal of Neculear Medicine, vol. 33, No. 4, 1992, pp. 558-569.
Geraldes et al., “Magnetic Field Dependence of Solvent Proton Relaxation Rates Induced by Gd3+and Mn2+Complexes of Various Polyaza Macrocyclic Ligands: Implications for NMR Imaging,” Magnetic Resonance in Medicine, pp. 242-250, vol. 3, 1986.
Hardy et al., “Superoxide Dismutase Mimetics Inhibit Neutrophil-Mediated Human Aortic Endothelial Cell Injury in Vitro,” J. Biol. Chem., 1994, pp. 18535-18540, vol. 269.
Jackels et al., “Aqueous Proton NMR Relaxation Enhancement by Manganese (II) Macrocyclic Complexes: Structure Relaxivity Relationships,” Inorganic Chemistry, 1992, pp. 234-239, vol. 31.
Jackels et al., “Paramagnetic Macrocyclic Complexes as Contrast Agents for MR Imaging: Proton Nuclear Relaxation Rate Enhancement in Aqueous Solution and in Rat Tissues,” Radiology, 1992, pp. 27-31, vol. 3.
Lennon et al., “New Conformationally Constrained Polyaa Macrocycles Prepared via the Bis(chloroacetamide) Method,” Tetrahedron Letters, 1994, pp. 853-856, vol. 35.
Maeda et al., “Antitumor Activity and Tissue Distribution of bis(bilato)-1,2,” Database Chemabs (Chemical Abstracts Service & Cancer Lett.), 1993, pp. 57-64, vol. 70.
Newton et al., “Synthesis and Characterization of the Mn(II) Complex of [15]aneN5,” J. Coord. Chem., 1988, pp. 265-277, vol. 19.
Teijin Ltd., Patent Abstracts of Japan corresponding to JP-A-03 197 468, 1991, Abstract No. 461 (C-0887), vol. 15.
Szczpaniak, “Nuclear Magnetic Spin-Lattice Releaxation of Water Protons Caused by Metal Cage Compounds,” Bioconjugate Chem., 1992, pp. 27-31, vol. 3.
Tosoh Corp., Patent Abstracts of Japan corresponding to JP-A-63 014 780, 1988, Abstract No. 219 (C-506), vol. 12.
Tsuchida et al., “Amphiphilic Porphinatoirons Having Steroid Groups and Their Oxygen-Adduct Formation in an Aqueous Medium,” Bull Chem. Soc. Japan, 1990, pp. 2323-2327, vol. 63.
Aston Karl W.
Henke Susan L.
Lennon Patrick J
Neumann William L.
Riley Dennis P.
Jones Dameron L.
Metaphore Pharmaceuticals, Inc.
Sonnenschein Nath & Rosenthal LLP
LandOfFree
Bioconjugates of metal complexes of nitrogen-containing... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Bioconjugates of metal complexes of nitrogen-containing..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bioconjugates of metal complexes of nitrogen-containing... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4014490