Bioconjugate-nanoparticle probes

Details Bioconjugate-nanoparticle probes Bioconjugate-nanoparticle probes

2007-03-06

2007-03-06

Riley, Jezia (Department: 1637)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S024300, C536S025300, C435S006120

Reexamination Certificate

active

10291291

ABSTRACT:
The invention provides nanoparticle-bioconjugate probes that are useful for detecting target analytes such as nucleic acids. The probes of the invention are stable towards heat and resistant to displacement by thiol containing compounds such as DTT (dithiothreitol).

REFERENCES:
patent: 4193983 (1980-03-01), Ullman et al.
patent: 4256834 (1981-03-01), Zuk et al.
patent: 4261968 (1981-04-01), Ullman et al.
patent: 4313734 (1982-02-01), Leuvering
patent: 4318707 (1982-03-01), Litman et al.
patent: 4650770 (1987-03-01), Liu et al.
patent: 4713348 (1987-12-01), Ullman
patent: 4853335 (1989-08-01), Olsen et al.
patent: 4868104 (1989-09-01), Kurn et al.
patent: 4996143 (1991-02-01), Heller et al.
patent: 5225064 (1993-07-01), Henkens et al.
patent: 5284748 (1994-02-01), Mroczkowski et al.
patent: 5288609 (1994-02-01), Engelhardt et al.
patent: 5294369 (1994-03-01), Shigekawa et al.
patent: 5360895 (1994-11-01), Hainfeld et al.
patent: 5384073 (1995-01-01), Shigekawa et al.
patent: 5384265 (1995-01-01), Kidwell et al.
patent: 5460831 (1995-10-01), Kossovsky et al.
patent: 5472881 (1995-12-01), Beebe et al.
patent: 5514602 (1996-05-01), Brooks, Jr. et al.
patent: 5521289 (1996-05-01), Hainfeld et al.
patent: 5543158 (1996-08-01), Gref et al.
patent: 5571726 (1996-11-01), Brooks, Jr. et al.
patent: 5599668 (1997-02-01), Stimpson et al.
patent: 5609907 (1997-03-01), Natan
patent: 5637508 (1997-06-01), Kidwell et al.
patent: 5665582 (1997-09-01), Kausch et al.
patent: 5681943 (1997-10-01), Letsinger et al.
patent: 5751018 (1998-05-01), Alivisatos et al.
patent: 5830986 (1998-11-01), Merrill et al.
patent: 5900481 (1999-05-01), Lough et al.
patent: 5939021 (1999-08-01), Hansen et al.
patent: 5990479 (1999-11-01), Weiss et al.
patent: 6025202 (2000-02-01), Natan
patent: 6149868 (2000-11-01), Natan et al.
patent: 6203989 (2001-03-01), Goldberg et al.
patent: 6214560 (2001-04-01), Yguerabide et al.
patent: 6251303 (2001-06-01), Bawendi et al.
patent: 6277489 (2001-08-01), Abbott et al.
patent: 6306610 (2001-10-01), Bawendi et al.
patent: 6361944 (2002-03-01), Mirkin et al.
patent: 6365418 (2002-04-01), Wagner et al.
patent: 6369206 (2002-04-01), Leone et al.
patent: 6417340 (2002-07-01), Mirkin et al.
patent: 6720147 (2004-04-01), Mirkin et al.
patent: 2002/0172953 (2002-11-01), Mirkin et al.
patent: 2003/0068622 (2003-04-01), Mirkin et al.
patent: 2003/0068638 (2003-04-01), Mirkin et al.
patent: 2004/0101889 (2004-05-01), Mirkin et al.
patent: 0 630 974 (1994-06-01), None
patent: 0 667 398 (1995-08-01), None
patent: WO 89/06801 (1989-07-01), None
patent: WO 90/02205 (1990-03-01), None
patent: WO 92/04469 (1992-03-01), None
patent: WO 93/10564 (1993-05-01), None
patent: WO 93/25709 (1993-12-01), None
patent: WO 94/29484 (1994-12-01), None
patent: WO 97/40181 (1997-10-01), None
patent: WO 98/04740 (1998-02-01), None
patent: WO 98/04740 (1998-02-01), None
patent: WO 98/10289 (1998-03-01), None
patent: WO 98/17317 (1998-04-01), None
patent: WO 99/23258 (1998-10-01), None
patent: WO 99/20789 (1999-04-01), None
patent: WO 99/21934 (1999-05-01), None
patent: WO 99/23258 (1999-05-01), None
patent: WO 99/60169 (1999-11-01), None
patent: WO 00/25136 (2000-05-01), None
patent: WO 01/00876 (2001-01-01), None
patent: WO 01/51665 (2001-07-01), None
patent: WO 01/73123 (2001-10-01), None
patent: WO 01/86301 (2001-11-01), None
patent: WO 02/04681 (2002-01-01), None
patent: WO 02/18643 (2002-03-01), None
patent: WO 02/36169 (2002-05-01), None
patent: WO 00/33079 (2002-06-01), None
patent: WO 02/46472 (2002-06-01), None
patent: WO 02/46483 (2002-06-01), None
patent: WO 2004/053105 (2004-06-01), None
Letsinger, R., et al., “Chemistry of Oligonucleotide-Gold Nanoparticle Conjugates,”Phosphorus, Sulfur and Silicon, vol. 144, p. 359-362 (1999).
Letsinger, R., et al., “Use of a Steroid Cyclic Disulfide Anchor in Constructing Gold Nanoparticle—Oligonucleotide Conjugates,”Bioconjugate Chem, p. 289-291 (2000).
Li Z., et al., “Multiple thiol-anchor capped DNA-gold nanoparticle conjugates,”Nucleic Acids Research, vol. 30, p. 1558-1562 (2002).
Nuzzo R., et al., “Spontaneously Organized Molecular Assemblies. 3. Preparation and Properties of Solution Adsorbed Monolayers of Organic Disulfides on Gold Surfaces,”J. Am. Chem. Soc., vol. 109, p. 2358-2368 (1987).
Otsuka, H., et al., “Quantitative and Reversible Lectin-Induced Association of Gold Nonoparticles Modified with α-Lactosyl-ω-mercapto-poly(ethyleneglycol),”J. Am. Chem. Soc., vol. 123, p. 8226-8230 (2001).
Wuelfing, P., et al., “Nanometer Gold Clusters Protected by Surface-Bound Monolayers of Thiolated Poly(ethylene glycol) Polymer Electrolyte,”J. Am. Chem. Soc., vol. 120, p. 12696-12697 (1998).
Alivisatos et al., “Organization of ‘nanocrystal molecules’ using DNA,”Nature, vol. 382, pp. 609-611 (1996).
Bain, et al., “Modeling Organic Surfaces with Self-Assembled Monolayers,”Angew. Chem. Int. Ed. Engl., vol. 28, pp. 506-512 (1989).
Bradley, “The Chemistry of Transition Metal Colloids,”Clusters and Colloids: From Theory to Applications, G. Schmid, Editor, BCH, Weinheim, New York, pp. 459-542 (1994).
Brust et al., “Novel Gold-Dithiol Nano-Networks with Non-Metallic Electronic Properties,”Adv. Mater., vol. 7, pp. 795-797 (1995).
Chen et al., “A Specific Quadrilateral Synthesized from DNA Branched Junctions,”J. Am. Chem. Soc., vol. 111, pp. 6402-6407 (1989).
Chen & Seeman, “Synthesis from DNA of a molecule with the connectivity of a cube,”Nature, vol. 350, pp. 631-633 (1991).
Chen et al., Crystal Structure of a Four-Stranded Intercalated DNA: d(C4)†‡Biochem., vol. 33, pp. 13540-13546 (1994).
Dagani, “Supramolecular Assemblies DNA to organize gold nanoparticles,”Chemical&Engineering News, p. 6-7, Aug. 19, 1996.
Dubois & Nuzzo, “Synthesis, Structure, and Properties of Model Organic Surfaces,”Annu. Rev. Phys. Chem., vol. 43, pp. 437-464 (1992).
Elghanian et al., “Selective Colorimetric Detection of Polynucleotides Based on the Distance-Dependent Optical Properties of Gold Nanoparticles,”Science, vol. 277, pp. 1078-1081 (1997).
Grabar et al., “Preparation and Characterization of Au Colloid Monolayers,”Anal. Chem. vol. 67, pp. 735-743 (1995).
Hacia et al., “Detection of heterozygous mutations in BRCA1 using high density oligonucleotide arrays and two-colour fluorescence analysis,”Nature Genet., vol. 14, pp. 441-447 (1996).
Jacoby, “Nanoparticles change color on binding to nucleotide target,”Chemical&Engineering News, p. 10, Aug. 25, 1997.
Letsinger et al., Use of Hydrophobic Substituents in Controlling Self-Assembly of Oligonucleotides,J. Am. Chem. Soc., vol. 115, pp. 7535-7536 (1993).
Letsinger et al., “Control of Excimer Emission and Photochemistry of Stilbene Units by Oligonucleotide Hybridization,”J. Am. Chem. Soc., vol. 116, pp. 811-812 (1994).
Marsh et al., “A new DNA nanostructure, the G-wire, imaged by scanning probe microscopy,”Nucleic Acids Res., vol. 23, pp. 696-700 (1995).
Mirkin, “H-DNA and Related Structures,”Annu. Review Biophys. Biomol. Struct., vol. 23, pp. 541-576 (1994).
Mirkin et al., “A DNA-based method for rationally assembling nanoparticles into macroscopic materials,”Nature, vol. 382, pp. 607-609 (1996).
Mirkin et al., “DNA-Induced Assembly of Gold Nanoparticles: A Method for Rationally Organizing Colloidal Particles into Ordered Macroscopic Materials,”Abstract249, Abstracts of Papers Part 1, 212 ACS National Meeting 0-8412-3402-7, American Chemical Society, Orlando, FL, Aug. 25-29, 1996.
Mucic et al., “Synthesis and characterizations of DNA with ferrocenyl groups attached to their 5′-termini: electrochemical characterization of a redox-active nucleotide monolayer,”Chem. Commun., pp. 555-557 (1996).
Mulvaney, “Surface Plasmon Spectroscopy of Na

Affiliated with

Also associated with

Rating

Bioconjugate-nanoparticle probes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bioconjugate-nanoparticle probes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bioconjugate-nanoparticle probes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3774622