Biocompatible titanium alloys

Details Biocompatible titanium alloys Biocompatible titanium alloys

2011-03-22

2011-03-22

McNeil, Jennifer C (Department: 1784)

Stock material or miscellaneous articles

Composite

Of metal

C428S386000, C428S701000, C623S011110, C623S023560, C623S001440

Reexamination Certificate

active

07910221

ABSTRACT:
Methods and compositions are disclosed for coating a biocompatible medical implant with a surface layer having antioxidant activity. In various embodiments, a surface layer described herein destroys the oxidative activity of a reactive oxygen species (ROS) upon contact. An ROS can be, for example, an ROS generated by neutrophils in vivo. In various embodiments, a surface layer comprises a titanium oxide layer that can comprise a rutile, an anatase or a perovskite crystal structure, and can include defects comprising Ti(III). In some embodiments, the oxide layer can further comprise a dopant such as niobium. In some embodiments, methods for forming a surface layer on a biocompatible medical implant having antioxidant activity are disclosed.

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