Biocompatible, surface modified materials and method of making t

Details Biocompatible, surface modified materials and method of making t Biocompatible, surface modified materials and method of making t

1992-11-18

1994-07-05

Beck, Shrive

Coating processes

Direct application of electrical, magnetic, wave, or...

Polymerization of coating utilizing direct application of...

427534, 427307, 156643, B05D 306

Patent

active

053265840

ABSTRACT:
The present invention includes methods of permanently modifying the surface of a substrate material so as to develop a microscopically smooth, biocompatible surface thereon. A portion of the substrate surface is first removed, as by etching, in a radio frequency plasma reactor using inert argon gas. A biocompatible polymeric material may be covalently grafted to the surface of the substrate material by radio frequency plasma-induced grafting. The biocompatible polymeric material is preferably the same as the substrate material but may be different. Alternatively, after etching, the surface of a substrate material may be subjected to radio frequency plasma sufficient to raise the temperature at the substrate surface to just above the glass transition temperature (T.sub.g) of the substrate material for a time sufficient to produce a microscopically smooth, biocompatible surface on the substrate material. Further, the present invention includes a prosthesis used in mammals, including an intraocular lens, having a polymeric material core and a biocompatible polymeric material covalently grafted to the polymer core by radio frequency plasma treatment.

REFERENCES:
patent: 2999056 (1961-09-01), Tanner
patent: 3228741 (1966-01-01), Becker
patent: 3880818 (1975-04-01), Shen et al.
patent: 3925178 (1975-12-01), Gesser et al.
patent: 3944709 (1976-03-01), Levy
patent: 3959105 (1976-05-01), Feneberg et al.
patent: 3961379 (1976-06-01), Highgate
patent: 3985697 (1976-10-01), Urbach
patent: 4055378 (1977-10-01), Feneberg et al.
patent: 4072769 (1978-02-01), Lidel
patent: 4096315 (1978-06-01), Kubacki
patent: 4099859 (1978-07-01), Merrill
patent: 4122942 (1978-10-01), Wolfson
patent: 4123308 (1978-10-01), Nowlin et al.
patent: 4131691 (1978-12-01), Morley et al.
patent: 4137365 (1979-01-01), Wydeven et al.
patent: 4143949 (1979-03-01), Chen
patent: 4189364 (1980-02-01), Aelion et al.
patent: 4214014 (1980-07-01), Hofer et al.
patent: 4240163 (1980-12-01), Galin
patent: 4277595 (1981-07-01), Deichert et al.
patent: 4311828 (1982-01-01), Imada et al.
patent: 4312575 (1982-01-01), Peyman et al.
patent: 4328257 (1982-05-01), Muehlberger et al.
patent: 4344981 (1982-08-01), Imada et al.
patent: 4405773 (1983-09-01), Loshaek et al.
patent: 4409258 (1983-10-01), Feurer et al.
patent: 4430458 (1984-02-01), Tighe et al.
patent: 4463148 (1984-07-01), Hofer et al.
patent: 4478873 (1984-10-01), Masso et al.
patent: 4560458 (1985-12-01), Ueno et al.
patent: 4632842 (1986-12-01), Karwoski et al.
patent: 4656083 (1987-04-01), Hoffman et al.
patent: 4718907 (1988-01-01), Karwoski et al.
patent: 4720512 (1988-01-01), Hu et al.
patent: 4731080 (1988-03-01), Galin
patent: 4865870 (1989-09-01), Hu et al.
patent: 4885077 (1989-12-01), Karakelle et al.
patent: 4919659 (1990-04-01), Horbett et al.
patent: 4927676 (1990-05-01), Williams et al.
patent: 5002582 (1991-03-01), Guire et al.
patent: 5080924 (1992-01-01), Kamel et al.
patent: 5091240 (1992-02-01), Ratner et al.
patent: 5093152 (1992-03-01), Bonet et al.
H. Yasuda, "Plasma for Modification of Polymers," J. Macromol. Sci.-Chem., A10(3), pp. 383-420 (1976).
Knight et al., "Surface Modification of Intraocular Lenses to Reduce Corneal Endothelial Damage," AM Intra-Ocular Implant Soc. J-vol. V, pp. 123-130, Apr. 1979.
Gazard et al., "Lithographic Technique Using Radiation-Induced Grafting of Acrylic Acid into Poly(Methyl Methacrylate)Films," Polymer Engineering and Science, vol. 20, No. 16, pp. 1069-1072 (1980).
K. L. Mittal, "Interfacial Chemistry and Adhesion: Recent Developments and Prospects," Pure & Appl. Chem., vol. 52, pp. 1295-1305 (1980).
Akovali et al., "Polymerization of Hexamethyldisiloxane by Plasma on Activated Charcoal: Investigation of Parameters," Journal of Applied Polymer Science, vol. 29, pp. 2617-2625 (1984).
Liu et al., "Polymethyl Methacrylate Resist Sensitivity Enhancement in X-Ray Lithography by In Situ Polymerization," Appl. Phys. Lett., 44(10), pp. 973-975, May 15, 1984.
Keates et al., "Coated Intraocular Lenses," Ophthalmic Surgery, vol. 18, No. 9, pp. 693-697 (1987).

Affiliated with

Also associated with

Rating

Biocompatible, surface modified materials and method of making t does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Biocompatible, surface modified materials and method of making t, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biocompatible, surface modified materials and method of making t will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-795052