Biocompatible, surface modified materials

Details Biocompatible, surface modified materials Biocompatible, surface modified materials

1993-04-14

1996-11-26

Isabella, David J.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Eye prosthesis

Intraocular lens

623 11, 623 66, 427 224, 427 225, 351160R, A61F 216

Patent

active

055780792

ABSTRACT:
A method of permanently modifying the surface of a substrate material so as to develop a microscopically smooth, biocompatible surface thereon comprises covalently grafting a biocompatible polymeric material to the surface of the substrate material by radio frequency plasma-induced grafting. The biocompatible polymeric material is preferably the same as the substrate material. In addition, a method of permanently modifying the surface of a substrate material comprises subjecting the substrate surface to radio frequency plasma sufficient to raise the temperature at the substrate material to just above the glass transition temperature (T.sub.g) of the substrate material for a time sufficient to produce a microscopically smooth, biocompatible surface on the substrate material. Further, a prosthesis used in mammals, including an intraocular lens, comprises a polymeric material core and a biocompatible polymeric material covalently grafted to the polymer core by radio frequency plasma induction.

REFERENCES:
patent: 2999056 (1961-09-01), Tanner
patent: 3228741 (1966-01-01), Becker
patent: 3880818 (1975-04-01), Shen et al.
patent: 3925178 (1975-12-01), Gesser et al.
patent: 3944709 (1976-03-01), Levy
patent: 3959105 (1976-05-01), Feneberg et al.
patent: 3961379 (1976-06-01), Highgate
patent: 3985697 (1976-10-01), Urbach
patent: 4055378 (1977-10-01), Feneberg et al.
patent: 4072769 (1978-02-01), Lidel
patent: 4096315 (1978-06-01), Kubacki
patent: 4099859 (1978-07-01), Merrill
patent: 4122942 (1978-10-01), Wolfson
patent: 4123308 (1978-10-01), Nowlin et al.
patent: 4131691 (1978-12-01), Morley et al.
patent: 4137365 (1979-01-01), Wydeven et al.
patent: 4143949 (1979-03-01), Chen
patent: 4189364 (1980-02-01), Aelion et al.
patent: 4214014 (1980-07-01), Hofer et al.
patent: 4240163 (1980-12-01), Galin
patent: 4277595 (1981-07-01), Deichert et al.
patent: 4311828 (1982-01-01), Imada et al.
patent: 4312575 (1982-01-01), Peyman et al.
patent: 4328257 (1982-05-01), Muehlberger et al.
patent: 4344981 (1982-08-01), Imada et al.
patent: 4405773 (1983-09-01), Loshaek et al.
patent: 4409258 (1983-10-01), Feurer et al.
patent: 4430458 (1984-02-01), Tighe et al.
patent: 4463148 (1984-07-01), Hofer et al.
patent: 4478873 (1984-10-01), Masso et al.
patent: 4560458 (1985-12-01), Ueno et al.
patent: 4632842 (1986-12-01), Karwoski et al.
patent: 4656083 (1987-04-01), Hoffman et al.
patent: 4718907 (1988-01-01), Karwoski et al.
patent: 4720512 (1988-01-01), Hu et al.
patent: 4731079 (1988-03-01), Stoy
patent: 4731080 (1988-03-01), Galin
patent: 4806382 (1989-02-01), Goldberg et al.
patent: 4836884 (1989-06-01), McAuslan
patent: 4851003 (1989-07-01), Lindstrom
patent: 4851009 (1989-07-01), Pinchue
patent: 4865870 (1989-09-01), Hu et al.
patent: 4885077 (1989-12-01), Karakelle et al.
patent: 4919659 (1990-04-01), Horbett et al.
patent: 4927676 (1990-05-01), Williams et al.
patent: 4959074 (1990-09-01), Halpern et al.
patent: 4979959 (1990-12-01), Guire
patent: 5002582 (1991-03-01), Guire et al.
patent: 5091204 (1992-02-01), Ratner et al.
patent: 5171267 (1992-12-01), Ratner et al.
patent: 5252628 (1993-10-01), Chirila et al.
H. Yasuda, "Plasma for Modification of Polymers", J. Macromol. Sci.-Chem., A10(3), pp. 383-420 (1976).
Knight et al., "Surface Modification of Intraocular Lenses to Reduce Corneal Endothelial Damage", AM Intra-Ocular Implant Soc. J-vol. V, pp. 123-130, Apr. 1979.
Gazard et al., "Lithographic Technique Using Radiation-Induced Grafting of Acrylic Acid into Poly (-Methyl Methacrylate) Films", Polymer Engineering and Science, vol. 20, No. 16, pp. 1069-1072 (1980).
K. L. Mittal, "Interfacial Chemistry and Adhesion: Recent Developments and Prospects", Pure & Appl. Chem., vol. 52, pp. 1295-1305 (1980).
Akovali et al., "Polymerization of Hexamethyldisiloxane by Plasma on Activated Charcal: Investigation of Parameters", Journal of Applied Polymer Science, vol. 29, pp. 2617-2625 (1984).
Lui et al., "Polymethyl Methacrylate Resist Sensitivity Enhancement in X-Ray Lithography by In Situ Polymerization", Appl. Phys. Lett., 44(10), pp. 973-975, May 15, 1984.
Keates et al., "Coated Intraocular Lenses", Ophthalmic Surgery, vol. 18, No. 9, pp. 693-697 (1987).

Affiliated with

Also associated with

Rating

Biocompatible, surface modified materials does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Biocompatible, surface modified materials, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biocompatible, surface modified materials will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1969783