Biocompatible substance with thromboresistance

Details Biocompatible substance with thromboresistance Biocompatible substance with thromboresistance

1988-08-03

1991-05-28

Page, Thurman

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424422, 424424, 424425, 424426, 523112, 523113, 6048901, 604266, 530300, A61F 200, A61K 922

Patent

active

050193937

ABSTRACT:
Disclosed is a biocompatible, thromboresistant substance useful for implantable and extracorporeal devices in contact with the vascular system, and methods for producing the same. The biocompatible, thromboresistant substance comprises a synthetic, biocompatible material, at least one biocompatible base coat layer adhered to at least one surface of the material, and a thrombogenesis inhibitor immobilized on the base coat layer via a component capable of binding the inhibitor. The thrombogenesis inhibitor is streptokinase, urokinase, tissue plasminogen activator, ATPase, 5'-nucleotidase, and active fragments and active analogs thereof.

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