Biocompatible protein or ligand immobilization system

Details Biocompatible protein or ligand immobilization system Biocompatible protein or ligand immobilization system

1987-07-13

1989-12-05

Benson, Robert

Stock material or miscellaneous articles

Coated or structually defined flake, particle, cell, strand,...

Particulate matter

428407, 428408, 428688, 428689, 435180, 435176, 436524, 436527, 436531, 436534, 436 85, 530389, 530403, 530413, 530815, B32B 3300, G01N 33547

Patent

active

048852074

ABSTRACT:
A support matrix generally useful for the immobilization of biologically active proteins is made by coating with a polymeric alcohol a core support of titania or a carbonaceous pyropolymer deposited on a high surface area refractory inorganic oxide, cross-linking the alcohol, and converting a portion of the hydroxyl moieties to sulfonate esters. Such supports covalently bind enzymes and antibodies via a strong carbon-nitrogen single bond to give, for example, an immobilized antibody system extremely resistant to leaching of the antibody, the cross-linked alcohol, or of metals from the core support.

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patent: 4753983 (1988-06-01), Ngo
Michael D. Klein and Robert Langer, Trends in Biotech., Jul., 1986, pp. 179-186.

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