Biocompatible polyorganosiloxane composition for cell culture ap

Chemistry: molecular biology and microbiology – Apparatus – Bioreactor

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427 2, 4273935, 428116, 428178, 4284111, 428447, 435287, 435301, 524 17, 524588, C08G 7704

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active

048227412

ABSTRACT:
A polyorganosiloxane composition having a biocompatible surface thereon is disclosed. The biocompatible surface results from the derivatization, or amination, of the surface intended for cell contact. More specifically, the present invention is a polyorganosiloxane composition in which the surface is either treated with a primary amine and optional peptide or the surface is co-cured with a primary amine-containing silane or siloxane. The aminated polyorganosiloxane has utility as a cell culture substrate or in a variety of artificial organ applicatons such as breast implants, synthetic blood vessels, joints, tendons and heart valves. A vacuum apparatus for use with specialized cell cultrue plates incorporating the biocompatible polyorganosiloxane composition is also disclosed.

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