Chemistry: molecular biology and microbiology – Apparatus – Bioreactor
Patent
1988-04-11
1989-04-18
Epstein, Henry F.
Chemistry: molecular biology and microbiology
Apparatus
Bioreactor
427 2, 4273935, 428116, 428178, 4284111, 428447, 435287, 435301, 524 17, 524588, C08G 7704
Patent
active
048227412
ABSTRACT:
A polyorganosiloxane composition having a biocompatible surface thereon is disclosed. The biocompatible surface results from the derivatization, or amination, of the surface intended for cell contact. More specifically, the present invention is a polyorganosiloxane composition in which the surface is either treated with a primary amine and optional peptide or the surface is co-cured with a primary amine-containing silane or siloxane. The aminated polyorganosiloxane has utility as a cell culture substrate or in a variety of artificial organ applicatons such as breast implants, synthetic blood vessels, joints, tendons and heart valves. A vacuum apparatus for use with specialized cell cultrue plates incorporating the biocompatible polyorganosiloxane composition is also disclosed.
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