Stock material or miscellaneous articles – Composite – Of silicon containing
Patent
1987-05-04
1988-12-06
Epstein, Henry F.
Stock material or miscellaneous articles
Composite
Of silicon containing
428116, 428178, 435287, 524 17, 524588, C08G 7704
Patent
active
047896019
ABSTRACT:
A polyorganosiloxane composition having a biocompatible surface thereon is disclosed. The biocompatible surface results from the derivatization, or amination, of the surface intended for cell contact. More specifically, the present invention is a polyorganosiloxane composition in which the surface is either treated with a primary amine and optional peptide or the surface is co-cured with a primary amine-containing silane or siloxane. The aminated polyorganosiloxane has utility as a cell culture substrate or in a variety of artificial organ applications such as brest implants, synthetic blood vessels, joints, tendons and heart valves. A vacuum apparatus for use with specialized cell culture plates incorporating the biocompatible polyorganosiloxane composition is also disclosed.
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