Biocompatible polymeric materials, methods of preparing such mat

Details Biocompatible polymeric materials, methods of preparing such mat Biocompatible polymeric materials, methods of preparing such mat

1996-11-18

1999-11-30

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Aftertreated polymer

514773, 525 541, 525426, 264 136, 264299, 523106, 522 87, A61K 4742, C08L 8900, C08J 324, C08F28304

Patent

active

059937963

ABSTRACT:
The present invention is directed to a biocompatible polymeric material and methods of making prepared by forming a mixture of collagen, a water-soluble ethylenically unsaturated compound and a cross-linking agent at a temperature of 30.degree. C. to 42.degree. C.; adjusting the pH of the mixture to 3.2 to 5.0; and polymerizing the mixture. The resulting material is rinsed in a physiologic solution at a temperature of 25.degree. C. to 80.degree. C. The resulting polymeric material has a modules of elasticity in the range of 10 to 27.times.10.sup.5 N/m.sup.2. Mechanical strength of the polymeric material is 20 to 100 times greater than polymeric material prepared by known methods. The material is optically transparent and is characterized by 95% or more light transmission in the visible spectrum and by resolution of 200 lines per mm for a +20D intraocular lens. The material is characterized by low protein absorption of about 0.1.times.10.sup.-3 .mu.g/mg and the material is resistant to proteolytic enzymes including pepsin, trypsin, chymotrypsin, and collagenase. The present invention is further directed to intraocular lenses and contact lenses produced from the present material, and the use of such lenses in patients having impaired vision to correct or improve such impaired vision.

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