Biocompatible polymer membranes and methods of preparation of th

Details Biocompatible polymer membranes and methods of preparation of th Biocompatible polymer membranes and methods of preparation of th

1993-02-01

1996-05-07

Kulkosky, Peter F.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424426, 521 27, C08J 520, A61F 200

Patent

active

055143784

ABSTRACT:
Biocompatible porous polymer membranes are prepared by dispersing salt particles in a biocompatible polymer solution. The solvent in which the polymer is dissolved is evaporated to produce a polymer/salt composite membrane. The polymer can then be heated and cooled at a predetermined constant rate to provide the desired amount of crystallinity. Salt particles are leached out of the membrane by immersing the membrane in water or another solvent for the salt but not the polymer. The membrane is dried, resulting in a porous, biocompatible membrane to which dissociated cells can attach and proliferate. A three-dimensional structure can be manufactured using the polymer membranes by preparing a contour drawing of the shape of the structure, determining the dimensions of thin cross-sectional layers of the shape, forming porous polymer membranes corresponding to the dimensions of the layers, and laminating the membranes together to form a three-dimensional matrix having the desired shape.

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Vacanti, J. P. "Beyond Transplantation", Arch. Surg., 123:545-549 (1988).
Vacanti, J. P. "Selective Cell Transplantation Using Bioabsorbable Artificial Polymers as Matrices", Journal of Pediatric Surgery, 23(1):3-9 (1988).

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