Biocompatible microcapsules

Details Biocompatible microcapsules Biocompatible microcapsules

1994-11-10

1998-10-13

Spear, James M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424490, 424493, 424497, 424423, 424424, 5147721, 5147722, 514777, 514773, A61K 954, A61K 962, A61K 964

Patent

active

058208828

ABSTRACT:
Biocompatible microcapsules useful for transplanting foreign material into an animal body, and the method of their production, are described, wherein the microcapsules contain an outermost layer of water soluble non-ionic polymers such as PEO to create resistance to cell adhesion on the surface of the microcapsules.

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Kiss et al., "Surface Grafting of Polyethyleneoxide Optimized by Means of OSCA"; Progr. Colloid & Polymer Sci. 74:113-119 (1987).
Bader, Robert, et al., "Watersoluble Polymers in Medicine," Die Angewandte Makromolekulare Chemie 123/124:457-485 (1984).
Pratten, Margaret K., and John B. Lloyd, "Micelle-forming block copolymers: Pinocytosis by macrophages and interaction with model membranes," Makromol. Chem. 186:725-733 (1985).

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