Biocompatible method for in situ production of functional platel

Details Biocompatible method for in situ production of functional platel Biocompatible method for in situ production of functional platel

1985-01-31

1986-08-26

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

422 24, 435 2, A61K 3514

Patent

active

046082557

ABSTRACT:
The present invention discloses the effect of ultraviolet (UV) radiation on platelet concentrates collected in a plastics container, particularly in a polypropylene bag. Samples irradiated at 310 nm for 30 minutes at a dose of 774 J/M.sup.2 show no loss of platelet function as determined by ADP, collagen, or ristocetin-induced aggregation. Lymphocytes isolated from irradiated units are unable to act as responders or stimulators in a mixed lymphocyte reaction. The invention provides a method of UV irradiation of platelet concentrates resulting in transfusible cell suspension unable to evoke immunological response while retaining normal platelet function.

REFERENCES:
patent: 2401131 (1946-05-01), Bensel
Lawler et al.-Thrombosis Research, vol. 14(23) (1979), pp. 489-494.
Lawler-Dissert Abst. Int. B-vol. 36, No. 11 (1976), p. 5410-B.
Roshchupkin et al.-Chem. Abst., vol. 99 (1983), p. 49648a.
Slitcher et al., Jol. of American Soc. of Hematology, 1984, Abstract entitled "Blood", vol. 64, No. 5, p. 231(a).
Biffa et al., British Jol. of Dermatology, 1979, Abstract entitled "Inhibition of Human Blood Platelet Aggression . . . ", pp. 679-683.
Lau et al., Science, vol. 221, 1983, Abstract entitled "Panecreatic Islet Allograft Prolongation by Donor-Specific . . . ", pp. 754-755.
Kripke, Immunological Reviews, 1984, No. 80, Abstract entitled "Immunological Unresponsiveness Induced by UV Radiation", pp. 87-102.
Lau et al., Science, vol. 223, 1984, Abstract entitled "Prolongation of Rat Islet Allograft Survival by . . . ", pp. 607-609.
Doery et al., Blood, vol. 42, 1973, Abstract entitled "Induction of Aggregation of Human Blood Platelets . . . ", pp. 551-555.

Affiliated with

Also associated with

Rating

Biocompatible method for in situ production of functional platel does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Biocompatible method for in situ production of functional platel, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biocompatible method for in situ production of functional platel will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2311758