Biocompatible metal surfaces

Details Biocompatible metal surfaces Biocompatible metal surfaces

1993-11-03

1994-10-18

Green, Randall L.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Implantable prosthesis

623 1, 623900, 623901, 424422, 424423, 427 224, A61F 202, A61F 206, A61F 224, A61F 276

Patent

active

053564332

ABSTRACT:
Metallic surfaces of medical devices or components of medical devices are provided that have enhanced biocompatibility properties. The surfaces are prepared by a two-step procedure including covalently linking an organosilane having amine reactive sites with the surface of the metallic member, typically through a metal oxide thereof. Thereafter, a biologically active agent is covalently linked to the organosilane coating. The two-step process is particularly advantageous for preparing medical devices in the form of stents which need to be bent and flexed during implantation procedures.

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